Synthesis and anti-microbial activity of new (1-alkyl-1h-1,2,3-triazol-4-yl)methyl-2hchromene-3-carboxylates : a click chemistry approach

A series of new 1,4 disubstituted (1-alkyl-1H-1,2,3-triazol-4-yl)methyl-2H-chromene-3- carboxylates (4ai–4eiii) have been efficiently synthesized in moderate to excellent yields by the 1,3 dipolar cycloaddition between 2-propynyl-2H-chromene-3-carboxylates 3a–e and various alkyl azides under Cu(I) c...

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Bibliographic Details
Published in:Journal of Saudi Chemical Society 2015, Vol.19 (4), p.372-378
Main Authors: Reddy, M. Koteswara, Rao, Y. Jayaprakash, Krupadanam, G. L. David
Format: Article
Language:English
Subjects:
Carboxylates
Chemical-biological activities
Synthesis
Triazoles
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Summary:A series of new 1,4 disubstituted (1-alkyl-1H-1,2,3-triazol-4-yl)methyl-2H-chromene-3- carboxylates (4ai–4eiii) have been efficiently synthesized in moderate to excellent yields by the 1,3 dipolar cycloaddition between 2-propynyl-2H-chromene-3-carboxylates 3a–e and various alkyl azides under Cu(I) catalyzed conditions. The structures of the synthesized compounds are established based on IR, NMR, MASS Spectrometric methods and elemental analyses. The antibacterial and antifungal activities of synthesized compounds were evaluated. Compounds 4biii, 4ei, 4dii, 4ai, 4aii, 4bii showed good activity against bacterial strains and the compounds 4bi, 4eii against fungal strains.
ISSN:1319-6103