Polysaccharides and ascorbic acid content and the effect of aqueous extract of Portulaca oleracea in high-fat diet-induced obesity, dyslipidemia and liver damage in albino wistar rats

The aim of the present study was to evaluate the hypolipidemic and antioxidant properties of aqueous extracts of Portulaca oleracea in experimental obese rats. Twenty four (24) apparently healthy male Wistar rats were grouped into four groups (6 rats in each): normal, Obese, Obese + Atorvastatine (1...

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Published in:Algerian Journal of Arid Environment : Revue des Sciences de la Terre et de la Vie. 2017, Vol.7 (2), p.16-26
Main Authors: Derouiche, Samir, Abbas, Kawthar, Djermoune, Manal
Format: Article
Language:eng ; fre
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Summary:The aim of the present study was to evaluate the hypolipidemic and antioxidant properties of aqueous extracts of Portulaca oleracea in experimental obese rats. Twenty four (24) apparently healthy male Wistar rats were grouped into four groups (6 rats in each): normal, Obese, Obese + Atorvastatine (100 mg kg-1 day-1) and Obese + P. oleracea (400 mg kg-1 day-1.) groups. All rats except those in the control group were made dyslipidemic using a high-fat cafeteria food. All drug administration was done orally for a period of four weeks. Administration of P. oleracea reduced the levels of TG (26.99%), TC (10.91%) and LDL (16.41%), which were elevated by obesity. Analysis of the effect of P. oleracea on antioxidant liver, revealed that P. oleracea potentially regulates lipid peroxides and protects organs from oxidation-associated damage. The markers of liver damage such as SGPT and SGOT levels that were elevated (p
ISSN:2170-1318
2588-1949