A mathematical framework for predicting thermal damage during bone electrostimulation

Purpose – Electric fields (EFs) are known to influence cell and tissue activity. This influence can be due to thermal or non-thermal effects. While the non-thermal effects are still matter of discussion, thermal effects might be detrimental for cell and tissue viability due to thermal damage, this f...

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Bibliographic Details
Published in:Compel 2015-07, Vol.34 (4), p.1085-1100
Main Authors: Vanegas-Acosta, Juan C, Lancellotti, V, Zwamborn, A.P.M
Format: Article
Language:English
Subjects:
Ablation
Arthritis
Biocompatibility
Biomechanics
Biomedical materials
Bones
Cartilage
Cell adhesion & migration
Cell growth
Damage
Damage accumulation
Dielectric properties
Dosimeters
Electric fields
Electrical & electronic engineering
Electrodes
Engineering
Formations
Growth factors
Heat
Heat conductivity
Hyperthermia
Magnetic fields
Mathematical analysis
Mathematical models
Matrix methods
Osteoarthritis
Soft tissues
Stem cells
Temperature effects
Viability
Wound healing
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Summary:Purpose – Electric fields (EFs) are known to influence cell and tissue activity. This influence can be due to thermal or non-thermal effects. While the non-thermal effects are still matter of discussion, thermal effects might be detrimental for cell and tissue viability due to thermal damage, this fact being exploited by applications like hyperthermia and tissue ablation. The paper aims to discuss these issues. Design/methodology/approach – In this work the authors investigate the influence of thermal damage in the consolidation of bone formation during electrostimulation (ES). The authors introduce a mathematical model describing the migration of osteoprogenitor cells, the thermal variation, the thermal damage accumulation and the formation of new bone matrix in an injury (fracture) site. Findings – Numerical results are in agreement with experimental data and show that EFs more intense than 7.5 V/cm are detrimental for the viability of osteoprogenitor cells and the formation of new bone. Originality/value – The model is suitable to conduct dosimetry studies in support of other different ES techniques aimed at improving bone and soft tissues repair.
ISSN:0332-1649
2054-5606
DOI:10.1108/COMPEL-09-2014-0241