Catalase catalyzes of peroxynitrite-mediated phenolic nitration

Catalase catalyzed the peroxynitrite-mediated nitration of 4-hydroxyphenylacetic acid. The curve for the pH dependence of nitration was similar to that for the reaction between peroxynitrite and phenol. Cyanide, azide, and 3-amino-1,2,4-triazole inhibited the nitration in a dose, ependent way. When...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1998-03, Vol.62 (3), p.448-452
Main Authors: Kono, Y. (Shimane Univ., Matsue (Japan)), Yamasaki, T, Ueda, A, Shibata, H
Format: Article
Language:English
Subjects:
ACIDE PHENOLIQUE
ACIDOS FENOLICOS
Action of physical and chemical agents on bacteria
Animals
bacterial killing
Bacteriology
BIOCHEMICAL REACTIONS
Biological and medical sciences
CATALASA
CATALASE
Catalase - metabolism
CATALIZADOR
CATALYSEUR
Catalysis
CATALYSTS
Cattle
ESCHERICHIA COLI
Escherichia coli - drug effects
Fundamental and applied biological sciences. Psychology
Hydrogen-Ion Concentration
Kinetics
Microbial Sensitivity Tests
Microbiology
NITRATE
NITRATES
Nitrates - metabolism
Nitrates - pharmacology
NITRATOS
NITRIFICACION
NITRIFICATION
Oxidants - metabolism
Oxidants - pharmacology
peroxynitrite
PHENOLIC ACIDS
phenolic nitration
Phenylacetates - metabolism
REACCIONES BIOQUIMICAS
REACTION BIOCHIMIQUE
SUPEROXIDE DISMUTASE
Superoxide Dismutase - metabolism
SUPEROXIDO DISMUTASA
SUPEROXYDE DISMUTASE
TOXICIDAD
TOXICITE
TOXICITY
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Summary:Catalase catalyzed the peroxynitrite-mediated nitration of 4-hydroxyphenylacetic acid. The curve for the pH dependence of nitration was similar to that for the reaction between peroxynitrite and phenol. Cyanide, azide, and 3-amino-1,2,4-triazole inhibited the nitration in a dose, ependent way. When catalase was mixed with peroxynitrite, Compound I was detected as an intermediate. Because azide was an electron donor for the peroxidatic action of catalase, and because 3-amino-1,2,4-triazole inhibited catalase activity by binding with Compound I, peroxynitrite-mediated phenolic nitration was probably accompanied by Compound I formation. Both catalase and superoxide dismutase protected Escherichia coli from peroxynitrite toxicity
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.62.448