Novel DPPH radical scavengers, bisorbicillinol and demethyltrichodimerol, from a fungus

In our screening program for antioxidants with DPPH radical scavenging activity, we isolated four yellowish compounds from the fermentation broth of Trichoderma sp. USF-2690 strain isolated from a soil sample: two were novel compounds designated bisorbicillinol (1) and demethyltrichodimerol (2), and...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1998, Vol.62 (4), p.661-666
Main Authors: Abe, N. (Shizuoka Univ. (Japan)), Murata, T, Hirota, A
Format: Article
Language:English
Subjects:
ACIDE SORBIQUE
ACIDO SORBICO
antioxidant
Biological and medical sciences
bisorbicillinol
CHEMICAL STRUCTURE
COMPOSE ORGANIQUE
COMPUESTOS ORGANICOS
demethyltrichodimerol
DPPH radical scavengers
DPPH radical scavenging compound
ESPECTROSCOPIA RMN
ESTRUCTURA QUIMICA
FREE RADICALS
General pharmacology
Medical sciences
NMR SPECTROSCOPY
ORGANIC COMPOUNDS
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
RADICAL LIBRE
RADICALES LIBRES
SEPARACION
SEPARATING
SEPARATION
SORBIC ACID
SPECTROSCOPIE RMN
STRUCTURE CHIMIQUE
TRICHODERMA
Trichoderma sp. USF-2690
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Summary:In our screening program for antioxidants with DPPH radical scavenging activity, we isolated four yellowish compounds from the fermentation broth of Trichoderma sp. USF-2690 strain isolated from a soil sample: two were novel compounds designated bisorbicillinol (1) and demethyltrichodimerol (2), and two were known compounds bisvertinolone (3) and trichodimerol (4). The structures of 1 and 2 were elucidated by spectroscopic evidence and chemical modification. Two compounds seemed to be the oxidized dimers of sorbicillin. In the evaluation of DPPH radical scavenging activity, bisorbicillinol gave the lowest ED50 value (31.4 mu-M) among the four compounds, equal to that of BHT (27.0 mu-M)
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.62.661