Two novel diterpenoids, erinacines H and I from the mycelia of Hericium erinaceum [Basidiomycotina]

Novel diterpenoids, erinacines H (1) and I (3), were isolated from the cultured mycelia of Hericium erinaceum. The structures of the compounds were determined by interpretation of the spectral data. Erinacine H showed stimulating activity of nerve growth factor (NGF)-synthesis.

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2000-11, Vol.64 (11), p.2402-2405
Main Authors: Lee, E.W. (Shizuoka Univ. (Japan). Faculty of Agriculture), Shizuki, K, Hosokawa, S, Suzuki, M, Suganuma, H, Inakuma, T, Li, J, Ohnishi Kameyama, M, Nagata, T, Furukawa, S, Kawagishi, H
Format: Article
Language:English
Subjects:
Animals
Astrocytes - cytology
Astrocytes - drug effects
Astrocytes - metabolism
Basidiomycota - chemistry
BASIDIOMYCOTINA
Biological and medical sciences
Diterpenes - chemistry
Diterpenes - isolation & purification
diterpenoid
DITERPENOIDS
erinacines H
erinacines I
General pharmacology
Hericium erinaceum
Medical sciences
MYCELIUM
nerve growth factor
Nerve Growth Factor - metabolism
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Rats
stimulator
STIMULI
Xylose - analogs & derivatives
Xylose - chemistry
Xylose - isolation & purification
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Summary:Novel diterpenoids, erinacines H (1) and I (3), were isolated from the cultured mycelia of Hericium erinaceum. The structures of the compounds were determined by interpretation of the spectral data. Erinacine H showed stimulating activity of nerve growth factor (NGF)-synthesis.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.64.2402