Y-700, a novel inhibitor of xanthine oxidase, suppresses the development of colon aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine-treated mice

Y-700, 1-[3-cyano-4-( 2,2-dimethylpropoxy)phenyl]. 1H-pyrazole-4-carboxylic acid, is a newly synthesized Inhibitor of xanthine oxidase. This study found that feeding of Y-700 suppressed the development of colonic aberrant crypt foci, precursor lesions of colon cancer, and cell proliferation in 1,2-d...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2005-01, Vol.69 (1), p.209-211
Main Authors: Hashimoto, T. (Hiroshima Univ. (Japan)), Fukunari, A, Yamada, I, Yanaka, N, Chen, D, Kato, N
Format: Article
Language:English
Subjects:
1,2-Dimethylhydrazine
1-[3-cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid (Y-700)
Animals
Biological and medical sciences
CARCINOGENESIS
CARCINOGENS
CELL DIVISION
cell proliferation
Cell Proliferation - drug effects
Colon - pathology
colon aberrant crypt foci
Colonic Diseases - chemically induced
Colonic Diseases - pathology
Colonic Diseases - prevention & control
Dose-Response Relationship, Drug
ENZYME INHIBITORS
Fundamental and applied biological sciences. Psychology
INTESTINES
Male
MICE
Mice, Inbred Strains
OXYGEN
Pyrazoles - pharmacology
reactive oxygen species
XANTHINE OXIDASE
Xanthine Oxidase - antagonists & inhibitors
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Summary:Y-700, 1-[3-cyano-4-( 2,2-dimethylpropoxy)phenyl]. 1H-pyrazole-4-carboxylic acid, is a newly synthesized Inhibitor of xanthine oxidase. This study found that feeding of Y-700 suppressed the development of colonic aberrant crypt foci, precursor lesions of colon cancer, and cell proliferation in 1,2-dimethylhydrazine-treated mice, accompanied by reduced serum urate. These results suggest that Y-700 is a useful agent for the prevention of colon tumorigenesis and that xanthine oxidase plays an important role in the development of colon cancer.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.69.209