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Y-700, a novel inhibitor of xanthine oxidase, suppresses the development of colon aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine-treated mice

Y-700, 1-[3-cyano-4-( 2,2-dimethylpropoxy)phenyl]. 1H-pyrazole-4-carboxylic acid, is a newly synthesized Inhibitor of xanthine oxidase. This study found that feeding of Y-700 suppressed the development of colonic aberrant crypt foci, precursor lesions of colon cancer, and cell proliferation in 1,2-d...

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Published in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2005-01, Vol.69 (1), p.209-211
Main Authors:	Hashimoto, T. (Hiroshima Univ. (Japan)), Fukunari, A, Yamada, I, Yanaka, N, Chen, D, Kato, N
Format:	Article
Language:	English
Subjects:	1,2-Dimethylhydrazine 1-[3-cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid (Y-700) Animals Biological and medical sciences CARCINOGENESIS CARCINOGENS CELL DIVISION cell proliferation Cell Proliferation - drug effects Colon - pathology colon aberrant crypt foci Colonic Diseases - chemically induced Colonic Diseases - pathology Colonic Diseases - prevention & control Dose-Response Relationship, Drug ENZYME INHIBITORS Fundamental and applied biological sciences. Psychology INTESTINES Male MICE Mice, Inbred Strains OXYGEN Pyrazoles - pharmacology reactive oxygen species XANTHINE OXIDASE Xanthine Oxidase - antagonists & inhibitors
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container_start_page	209
container_title	Bioscience, biotechnology, and biochemistry
container_volume	69
creator	Hashimoto, T. (Hiroshima Univ. (Japan)) Fukunari, A Yamada, I Yanaka, N Chen, D Kato, N
description	Y-700, 1-[3-cyano-4-( 2,2-dimethylpropoxy)phenyl]. 1H-pyrazole-4-carboxylic acid, is a newly synthesized Inhibitor of xanthine oxidase. This study found that feeding of Y-700 suppressed the development of colonic aberrant crypt foci, precursor lesions of colon cancer, and cell proliferation in 1,2-dimethylhydrazine-treated mice, accompanied by reduced serum urate. These results suggest that Y-700 is a useful agent for the prevention of colon tumorigenesis and that xanthine oxidase plays an important role in the development of colon cancer.
doi_str_mv	10.1271/bbb.69.209
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These results suggest that Y-700 is a useful agent for the prevention of colon tumorigenesis and that xanthine oxidase plays an important role in the development of colon cancer.</description><subject>1,2-Dimethylhydrazine</subject><subject>1-[3-cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid (Y-700)</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>CARCINOGENESIS</subject><subject>CARCINOGENS</subject><subject>CELL DIVISION</subject><subject>cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>Colon - pathology</subject><subject>colon aberrant crypt foci</subject><subject>Colonic Diseases - chemically induced</subject><subject>Colonic Diseases - pathology</subject><subject>Colonic Diseases - prevention & control</subject><subject>Dose-Response Relationship, Drug</subject><subject>ENZYME INHIBITORS</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>INTESTINES</subject><subject>Male</subject><subject>MICE</subject><subject>Mice, Inbred Strains</subject><subject>OXYGEN</subject><subject>Pyrazoles - pharmacology</subject><subject>reactive oxygen species</subject><subject>XANTHINE OXIDASE</subject><subject>Xanthine Oxidase - antagonists & inhibitors</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNptkU2LFDEQhhtR3NnVi3clIF5kesxXp7uPy-L6wYIe9OAppJOKnSXdaZOMbvtz_KVmmJG9CAWB4nmr3tRbVc8I3hHakjfDMOxEv6O4f1BtCONtLXrePqw2uCei7nhDzqrzlG4xLo2GPK7OSCNEw7tuU_35VrcYb5FCc_gJHrl5dIPLIaJg0Z2a8-hmQOHOGZVgi9J-WSKkBAnlEZCBognLBHM-8Dr4MCM1QIxFiXRcl4xs0A6p2SAN3qMlBu8sRJVdQd2MyJbWxk2Qx9WPq4nqd1lY5wgqg0GT0_CkemSVT_D09F5UX6_ffrl6X998evfh6vKm1kKwXDPAAxUELDEEWyBCM9AW64YTDpQNhikuFIeOYdK3qu0pVr3WDWPcYNsYdlG9PM4tHn_sIWV5G_ZxLisl4bzvCG2oKNTrI6VjSCmClUt0k4qrJFge4pAlDil6WeIo8IvTyP0wgblHT_cvwKsToJJW3pa7aZfuOdGy4u_ANUfOzTbESf0K0RuZ1epD_Cdi_zXw_KizKkj1PRbs42eKcVOKlq__BaSWr4U</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>Hashimoto, T. 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source	Oxford Journals Online; EZB Electronic Journals Library
subjects	1,2-Dimethylhydrazine 1-[3-cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid (Y-700) Animals Biological and medical sciences CARCINOGENESIS CARCINOGENS CELL DIVISION cell proliferation Cell Proliferation - drug effects Colon - pathology colon aberrant crypt foci Colonic Diseases - chemically induced Colonic Diseases - pathology Colonic Diseases - prevention & control Dose-Response Relationship, Drug ENZYME INHIBITORS Fundamental and applied biological sciences. Psychology INTESTINES Male MICE Mice, Inbred Strains OXYGEN Pyrazoles - pharmacology reactive oxygen species XANTHINE OXIDASE Xanthine Oxidase - antagonists & inhibitors
title	Y-700, a novel inhibitor of xanthine oxidase, suppresses the development of colon aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine-treated mice
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