Prolyl endopeptidase and thrombin inhibitory diterpenoids from the bark of Xylopia aethiopica

The inhibitory effects of seven diterpenes, belonging to three different structural classes and isolated from the bark of Xylopia aethiopica, were investigated against the enzymes prolyl endopeptidase (PEP) and alpha-thrombin. Five compounds exhibited inhibitory activity against them.

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2005-09, Vol.69 (9), p.1763-1766
Main Authors: Diderot, N.T.(University of Yaounde I (Cameroon)), Silvere, N, Yasin, A, Zareen, S, Fabien, Z, Etienne, T, Choudhary, M.I, Rahman, A.U
Format: Article
Language:English
Subjects:
Animals
ANNONA SQUAMOSA
Annonaceae - enzymology
Anticoagulants - chemistry
Anticoagulants - therapeutic use
BARK
Biological and medical sciences
CORTEZA
diterpene
Diterpenes - chemistry
Diterpenes - classification
Diterpenes - therapeutic use
DITERPENOIDE
DITERPENOIDS
DITERPENOS
Drug Evaluation, Preclinical
ECORCE
enzyme inhibition
Fundamental and applied biological sciences. Psychology
GENERO HUMANO
GENRE HUMAIN
Inhibitory Concentration 50
MANKIND
PEPTIDASAS
PEPTIDASE
PEPTIDASES
Phytotherapy
Plant Bark - chemistry
prolyl endopeptidase
Serine Endopeptidases - therapeutic use
thrombin
Thrombin - antagonists & inhibitors
Xylopia aethiopica
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Description
Summary:The inhibitory effects of seven diterpenes, belonging to three different structural classes and isolated from the bark of Xylopia aethiopica, were investigated against the enzymes prolyl endopeptidase (PEP) and alpha-thrombin. Five compounds exhibited inhibitory activity against them.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.69.1763