Elevation of the hepatic level of albumin mRNA in rats fed a non-protein diet supplemented with sulfur-containing amino acids and threonine

A nitrogen-sparing action of sulfur-containing amino acids and threonine in rats fed a non-protein diet has been reported from our laboratory. The nutritional significance of dietary sulfur-containing amino acids and threonine on the expression of the albumin gene was investigated. An elevated level...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1993, Vol.57 (3), p.471-474
Main Authors: Hitomi, Y. (Nagoya Univ. (Japan)), Ito, K, Chiba, J, Yoshida, A
Format: Article
Language:English
Subjects:
ACIDE AMINE
ALBUMINAS
ALBUMINE
ALBUMINS
AMINO ACIDS
AMINOACIDOS
ARN MENSAJERO
ARN MESSAGER
AZUFRE
Biological and medical sciences
DIET
DIETA
Feeding. Feeding behavior
FOIE
Fundamental and applied biological sciences. Psychology
HIGADO
LIVER
MESSENGER RNA
PROTEINAS
PROTEINE
PROTEINS
RAT
RATA
RATS
REGIME ALIMENTAIRE
SOUFRE
SULPHUR
THREONINE
TREONINA
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:A nitrogen-sparing action of sulfur-containing amino acids and threonine in rats fed a non-protein diet has been reported from our laboratory. The nutritional significance of dietary sulfur-containing amino acids and threonine on the expression of the albumin gene was investigated. An elevated level of serum albumin and its mRNA in liver was observed in rats fed a non-protein diet supplemented with sulfurcontaining amino acids and threonine, but the level of albumin mRNA of the group supplemented with cystine and threonine was much higher than that of the methionine and threonine supplemented group. Nuclear run-on assay showed an enhanced rate of albumin gene transcription in liver nuclei of rats fed the cystine and threonine supplemented diet. We showed the evidence that cystine is a more efficient amino acid than methionine to maintain the expression of the albumin gene at a high level in rats fed a nonprotein diet.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.57.471