Y-chromosomal delections - a risk factor for male infertility

In this study, contribution of micro-deletion towards male infertility among Pakistani male individuals has been described. Our analyses involved evaluation of seven genetic markers spanning the AZFa, b and c region among infertile males and observed micro-deletions were compared with the control he...

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Bibliographic Details
Published in:International journal of agriculture and biology 2009-01, Vol.11 (1), p.110-112
Main Authors: Siddiqi, S. (Institute of Biomedical and Genetic Engineering, Islamabad (Pakistan)), Siddiq, A. (ICSI Center, Pak-Saudi Tower, Islamabad (Pakistan)), Majeed, K. (COMSATS Inst. of Information Technology, Islamabad (Pakistan)), Mansoor, A. (COMSATS Inst. of Information Technology, Islamabad (Pakistan)), Qamer, R. (COMSATS Inst. of Information Technology, Islamabad (Pakistan)), Mazhar, K. (ICSI Center, Pak-Saudi Tower, Islamabad (Pakistan)), Ashraf, N. (ICSI Center, Pak-Saudi Tower, Islamabad (Pakistan)), Kafeel, S. (Salma and Kafeel Medicial Center, Islamabad (Pakistan)), Khanum, A. (Pir Mehr Ali Shah Arid Agriculture Univ., Rawalpindi (Pakistan)), Khan, K.M. (Pir Mehr Ali Shah Arid Agriculture Univ., Rawalpindi (Pakistan))
Format: Article
Language:English
Subjects:
CHROMOSOMES
GENETIC MARKERS
MALE INFERTILITY
RISK FACTORS
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Summary:In this study, contribution of micro-deletion towards male infertility among Pakistani male individuals has been described. Our analyses involved evaluation of seven genetic markers spanning the AZFa, b and c region among infertile males and observed micro-deletions were compared with the control healthy fertile counterparts. Data revealed AZFa deletion in 2% infertile azoospermic and oligospermic males, while the AZFb and AZFc deletions were found in 3.8 and 5.8% infertile males, of the total with male respectively. These deletions were found solely in non-obstructive azoospermic patients, which consisted of 17.6% non-obstructive infertile males. Our data clearly demonstrate association of Y-chromosomal micro-deletions infertility.
ISSN:1560-8530
1814-9596