chicken leukocyte receptor complex encodes a primordial, activating, high-affinity IgY Fc receptor

Fc receptors are key players of the immune system that link the fine specificity of immunoglobulins and innate effector responses. Here, we describe a nonmammalian Fcγ receptor, CHIR-AB1, a member of the leukocyte receptor complex, that binds IgY with high affinity with its single Ig domain. It is e...

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Published in:Proceedings of the National Academy of Sciences - PNAS 2007-07, Vol.104 (28), p.11718-11723
Main Authors: Viertlboeck, Birgit C, Schweinsberg, Sonja, Hanczaruk, Matthias A, Schmitt, Ramona, Du Pasquier, Louis, Herberg, Friedrich W, Göbel, Thomas W
Format: Article
Language:English
Subjects:
Animals
Antibody Affinity - immunology
B lymphocytes
Biological Sciences
Calcium
Cell Line
Cell lines
Chickens
Chickens - immunology
Fc receptors
Genes
Immune system
Immunoglobulins
Immunoglobulins - metabolism
Immunology
Leukocytes
Leukocytes - immunology
Leukocytes - metabolism
Ligands
Macrophages
Molecular Sequence Data
Natural killer cells
Poultry
Protein Binding - immunology
Receptors
Receptors, Fc - genetics
Receptors, Fc - metabolism
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cited_by cdi_FETCH-LOGICAL-c620t-793e4004e99d27960c050645d9a10071cd4ac3891e0e84252fdb871b6d432c283
cites cdi_FETCH-LOGICAL-c620t-793e4004e99d27960c050645d9a10071cd4ac3891e0e84252fdb871b6d432c283
container_end_page 11723
container_issue 28
container_start_page 11718
container_title Proceedings of the National Academy of Sciences - PNAS
container_volume 104
creator Viertlboeck, Birgit C
Schweinsberg, Sonja
Hanczaruk, Matthias A
Schmitt, Ramona
Du Pasquier, Louis
Herberg, Friedrich W
Göbel, Thomas W
description Fc receptors are key players of the immune system that link the fine specificity of immunoglobulins and innate effector responses. Here, we describe a nonmammalian Fcγ receptor, CHIR-AB1, a member of the leukocyte receptor complex, that binds IgY with high affinity with its single Ig domain. It is expressed on immature and mature B lymphocytes, monocytes, macrophages, and natural killer cells and harbors motifs of activating and inhibitory Fc receptors. In the absence of FcεRIγ, CHIR-AB1 can be expressed on B cells but cross-linking does not induce intracellular calcium release. In contrast, cells expressing CHIR-AB1 and FcεRIγ are triggered to release intracellular calcium upon stimulation with heat-aggregated IgY. CHIR-AB1 thus represents a primordial Fc receptor that combines features of different mammalian counterparts.
doi_str_mv 10.1073/pnas.0702011104
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ispartof Proceedings of the National Academy of Sciences - PNAS, 2007-07, Vol.104 (28), p.11718-11723
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1091-6490
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source JSTOR Archival Journals and Primary Sources Collection; PubMed Central
subjects Animals
Antibody Affinity - immunology
B lymphocytes
Biological Sciences
Calcium
Cell Line
Cell lines
Chickens
Chickens - immunology
Fc receptors
Genes
Immune system
Immunoglobulins
Immunoglobulins - metabolism
Immunology
Leukocytes
Leukocytes - immunology
Leukocytes - metabolism
Ligands
Macrophages
Molecular Sequence Data
Natural killer cells
Poultry
Protein Binding - immunology
Receptors
Receptors, Fc - genetics
Receptors, Fc - metabolism
title chicken leukocyte receptor complex encodes a primordial, activating, high-affinity IgY Fc receptor
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