effect of the phytoestrogens genistein, daidzein, and equol on the growth of tamoxifen-resistant T47D/PKCalpha

Soy supplements are often consumed by women for alleviating menopausal symptoms or for the perceived protective effects against breast cancer. More concerning is the concurrent consumption of soy isoflavones with tamoxifen (TAM) for prevention or treatment of breast cancer. We previously described a...

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Bibliographic Details
Published in:Nutrition and cancer 2007, Vol.58 (2), p.222-229
Main Authors: Tonetti, D.A, Zhang, Y, Zhao, H, Lim, S.B, Constantinou, A.I
Format: Article
Language:English
Subjects:
animal models
breast neoplasms
cell lines
cell proliferation
cultured cells
daidzein
disease models
drug resistance
equol
genistein
in vitro studies
isoflavones
mice
nutrient-drug interactions
plant estrogens
tamoxifen
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Summary:Soy supplements are often consumed by women for alleviating menopausal symptoms or for the perceived protective effects against breast cancer. More concerning is the concurrent consumption of soy isoflavones with tamoxifen (TAM) for prevention or treatment of breast cancer. We previously described a T47D:A18/protein kinase C (PKC)alphaTAM-resistant tumor model that exhibits autonomous growth and estradiol-induced tumor regression. We compared the estrogenicity of the isoflavones genistein, daidzein, and the daidzein metabolite equol in the parental T47D:A18 and T47D:A18/PKCalpha cell lines in vitro and in vivo. Whereas equol exerts estrogenic effects on T47D:A18 cells in vitro, none of the isoflavones stimulated T47D:A18 tumor growth. T47D:A18/PKCalpha tumor growth was partially stimulated by genistein, yet partially inhibited by daidzein. Interestingly, coadministration of TAM with either daidzein or genistein produced tumors of greater size than with TAM alone. These findings suggest that simultaneous consumption of isoflavone supplements with TAM may not be safe.
ISSN:0163-5581
1532-7914