Comparison of the Effects of Leishmania major or Leishmania donovani Infection on Macrophage Gene Expression

The intracellular parasite Leishmania causes a wide spectrum of human disease, ranging from self-resolving cutaneous lesions to fatal visceral disease, depending on the species of Leishmania involved. The mechanisms by which different Leishmania species cause different pathologies are largely unknow...

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Bibliographic Details
Published in:Infection and Immunity 2008-03, Vol.76 (3), p.1186-1192
Main Authors: Gregory, David J, Sladek, Robert, Olivier, Martin, Matlashewski, Greg
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blotting, Western
Bone marrow
Chromium
Cyclooxygenase-2
Fundamental and applied biological sciences. Psychology
Fungal and Parasitic Infections
GADD45 protein
Gene expression
Gene Expression Profiling
Gene Expression Regulation
Hsp70 protein
Infection
Leishmania donovani
Leishmania donovani - immunology
Leishmania major
Leishmania major - immunology
Life cycle. Host-agent relationship. Pathogenesis
Lymphocytes T
Macrophages
Macrophages - immunology
Macrophages - parasitology
Matrix metalloproteinase
Metallothionein
Mice
Mice, Inbred BALB C
Oligonucleotide Array Sequence Analysis
Parasites
Promastigotes
Prostaglandin E
Protozoa
Reverse Transcriptase Polymerase Chain Reaction
Spermidine
Spermine
Statistical analysis
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Summary:The intracellular parasite Leishmania causes a wide spectrum of human disease, ranging from self-resolving cutaneous lesions to fatal visceral disease, depending on the species of Leishmania involved. The mechanisms by which different Leishmania species cause different pathologies are largely unknown. We have addressed this question by comparing the gene expression profiles of bone marrow-derived macrophages infected with either Leishmania donovani or L. major promastigotes. We found that the two species had very similar effects on macrophage gene expression. Both species caused a small (
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.01320-07