Genetic Vaccination against Murine Cysticercosis by Using a Plasmid Vector Carrying Taenia solium Paramyosin

A plasmid vector carrying the immunoprotective amino-terminal fragment of Taenia solium paramyosin (VW2-1) was designed for genetic vaccination studies. Mice that were genetically immunized with VW2-1 and challenged by intraperitoneal inoculation of Taenia crassiceps cysticerci showed 43 to 48% redu...

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Bibliographic Details
Published in:Infection and Immunity 2005-03, Vol.73 (3), p.1895-1897
Main Authors: Solís, Carlos F, Ostoa-Saloma, Pedro, Lugo-Martínez, Verónica H, Johnston, Stephen Albert, Laclette, Juan Pedro
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cysticercosis
Cysticercosis - parasitology
Cysticercosis - prevention & control
Diseases caused by cestodes
Female
Fundamental and applied biological sciences. Psychology
Fungal and Parasitic Infections
Genetic Vectors
Helminthic diseases
Infectious diseases
Medical sciences
Mice
Mice, Inbred BALB C
Microbiology
Parasitic diseases
Plasmids
Taenia crassiceps
Taenia solium - genetics
Taenia solium - immunology
Taenia solium - isolation & purification
Tropomyosin - genetics
Tropomyosin - immunology
Vaccination
Vaccines, DNA - administration & dosage
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Summary:A plasmid vector carrying the immunoprotective amino-terminal fragment of Taenia solium paramyosin (VW2-1) was designed for genetic vaccination studies. Mice that were genetically immunized with VW2-1 and challenged by intraperitoneal inoculation of Taenia crassiceps cysticerci showed 43 to 48% reductions in the parasite burden, values which were similar to values obtained previously when the recombinant protein was used.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.73.3.1895-1897.2005