carbohydrate fraction, AIP1, from Artemisia iwayomogi down-regulates Fas gene expression and suppresses apoptotic death of the thymocytes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin

Apoptotic death of mouse thymocytes in vitro, as induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), involves the up-regulation of Fas gene expression, while a carbohydrate fraction, AIP1, from Artemisia iwayomogi suppresses the death of thymocytes in culture along with the down-regulation of Fas...

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Bibliographic Details
Published in:Biotechnology letters 2005, Vol.27 (4), p.253-257
Main Authors: Ji, H.J, Yeo, H.K, Lee, N.H, Hwang, J.S, Koo, K.A, Cheong, S.W, Park, J.H, Oh, G.S, Yoon, C.S, Youn, H.J
Format: Article
Language:English
Subjects:
apoptosis
Artemisia
Artemisia iwayomogi
carbohydrates
mice
tetrachlorodibenzo-p-dioxin
thymocytes
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Summary:Apoptotic death of mouse thymocytes in vitro, as induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), involves the up-regulation of Fas gene expression, while a carbohydrate fraction, AIP1, from Artemisia iwayomogi suppresses the death of thymocytes in culture along with the down-regulation of Fas gene expression. We have now investigated whether the AIP1 fraction modulates TCDD-induced thymocyte death. When treated with TCDD and AIP1 fraction together, the thymocytes do not show apoptosis induced by the TCDD treatment. The AIP1 supplementation to the TCDD treatment also down-regulates the TCDD-induced Fas gene up-regulation. These findings indicate that the AIP1 fraction suppresses TCDD-induced thymocyte apoptosis through the modulation of Fas gene expression.
ISSN:0141-5492
1573-6776
DOI:10.1007/s10529-004-8294-2