Probiotics Reduce Enterohemorrhagic Escherichia coli O157:H7- and Enteropathogenic E. coli O127:H6-Induced Changes in Polarized T84 Epithelial Cell Monolayers by Reducing Bacterial Adhesion and Cytoskeletal Rearrangements

The aim of this study was to determine if probiotics reduce epithelial injury following exposure to Escherichia coli O157:H7 and E. coli O127:H6. The pretreatment of intestinal (T84) cells with lactic acid-producing bacteria reduced the pathogen-induced drop in transepithelial electrical resistance....

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Bibliographic Details
Published in:Infection and Immunity 2005-08, Vol.73 (8), p.5183-5188
Main Authors: Sherman, Philip M, Johnson-Henry, Kathene C, Yeung, Helen P, Ngo, Peter S. C, Goulet, Jacques, Tompkins, Thomas A
Format: Article
Language:English
Subjects:
Actinin - metabolism
Bacterial Adhesion - physiology
Bacteriology
Biological and medical sciences
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Cytoskeleton - metabolism
Epithelial Cells - metabolism
Epithelial Cells - microbiology
Escherichia coli Infections - metabolism
Escherichia coli Infections - therapy
Escherichia coli O157 - metabolism
Fundamental and applied biological sciences. Psychology
Humans
Lactobacillus acidophilus - metabolism
Microbiology
Miscellaneous
Probiotics - metabolism
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Summary:The aim of this study was to determine if probiotics reduce epithelial injury following exposure to Escherichia coli O157:H7 and E. coli O127:H6. The pretreatment of intestinal (T84) cells with lactic acid-producing bacteria reduced the pathogen-induced drop in transepithelial electrical resistance. These findings demonstrate that probiotics prevent epithelial injury induced by attaching-effacing bacteria.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.73.8.5183-5188.2005