Mycobacterium avium subsp. paratuberculosis, Genetic Susceptibility to Crohn's Disease, and Sardinians: the Way Ahead

Thepresent study was performed to determine what proportion of people inSardinia with or without Crohn's disease were infected withMycobacterium avium subspecies paratuberculosis andhad a preponderance of allelic variants of Nod2, an intracellularprotein involved in Crohn's disease suscept...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2005-10, Vol.43 (10), p.5275-5277
Main Authors: Sechi, Leonardo A, Gazouli, Maria, Ikonomopoulos, John, Lukas, John C, Scanu, Antonio M, Ahmed, Niyaz, Fadda, Giovanni, Zanetti, Stefania
Format: Article
Language:English
Subjects:
Biological and medical sciences
Crohn Disease - epidemiology
Crohn Disease - etiology
Crohn Disease - genetics
Crohn Disease - microbiology
Female
Fundamental and applied biological sciences. Psychology
Genetic Predisposition to Disease
Humans
Infectious diseases
Intracellular Signaling Peptides and Proteins - genetics
Italy
Male
Medical sciences
Microbiology
Mycobacteriology and Aerobic Actinomycetes
Mycobacterium avium subsp. paratuberculosis - isolation & purification
Nod2 Signaling Adaptor Protein
Paratuberculosis - complications
Paratuberculosis - epidemiology
Paratuberculosis - microbiology
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Summary:Thepresent study was performed to determine what proportion of people inSardinia with or without Crohn's disease were infected withMycobacterium avium subspecies paratuberculosis andhad a preponderance of allelic variants of Nod2, an intracellularprotein involved in Crohn's disease susceptibility. Genetic analysis ofthe alleles of the NOD2/CARD15 gene (insC3020,G908R, and R702W alleles), linked to susceptibility orgenetic predisposition to Crohn's disease in humans, wascarried out on specimens from 37 Crohn's disease patients and 34patients without Crohn's disease. Our results show that more than 70percent of people in Sardinia with Crohn's disease carry at least oneof the susceptibility-associated NOD2/CARD15 alleles andwere infected with Mycobacterium avium subspeciesparatuberculosis.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.43.10.5275-5277.2005