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Mycobacterium avium subsp. paratuberculosis, Genetic Susceptibility to Crohn's Disease, and Sardinians: the Way Ahead
Thepresent study was performed to determine what proportion of people inSardinia with or without Crohn's disease were infected withMycobacterium avium subspecies paratuberculosis andhad a preponderance of allelic variants of Nod2, an intracellularprotein involved in Crohn's disease suscept...
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| Published in: | Journal of Clinical Microbiology 2005-10, Vol.43 (10), p.5275-5277 |
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| creator | Sechi, Leonardo A Gazouli, Maria Ikonomopoulos, John Lukas, John C Scanu, Antonio M Ahmed, Niyaz Fadda, Giovanni Zanetti, Stefania |
| description | Thepresent study was performed to determine what proportion of people inSardinia with or without Crohn's disease were infected withMycobacterium avium subspecies paratuberculosis andhad a preponderance of allelic variants of Nod2, an intracellularprotein involved in Crohn's disease susceptibility. Genetic analysis ofthe alleles of the NOD2/CARD15 gene (insC3020,G908R, and R702W alleles), linked to susceptibility orgenetic predisposition to Crohn's disease in humans, wascarried out on specimens from 37 Crohn's disease patients and 34patients without Crohn's disease. Our results show that more than 70percent of people in Sardinia with Crohn's disease carry at least oneof the susceptibility-associated NOD2/CARD15 alleles andwere infected with Mycobacterium avium subspeciesparatuberculosis. |
| doi_str_mv | 10.1128/JCM.43.10.5275-5277.2005 |
| format | article |
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Genetic analysis ofthe alleles of the NOD2/CARD15 gene (insC3020,G908R, and R702W alleles), linked to susceptibility orgenetic predisposition to Crohn's disease in humans, wascarried out on specimens from 37 Crohn's disease patients and 34patients without Crohn's disease. Our results show that more than 70percent of people in Sardinia with Crohn's disease carry at least oneof the susceptibility-associated NOD2/CARD15 alleles andwere infected with Mycobacterium avium subspeciesparatuberculosis.</description><identifier>ISSN: 0095-1137</identifier><identifier>EISSN: 1098-660X</identifier><identifier>DOI: 10.1128/JCM.43.10.5275-5277.2005</identifier><identifier>PMID: 16207995</identifier><identifier>CODEN: JCMIDW</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Biological and medical sciences ; Crohn Disease - epidemiology ; Crohn Disease - etiology ; Crohn Disease - genetics ; Crohn Disease - microbiology ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic Predisposition to Disease ; Humans ; Infectious diseases ; Intracellular Signaling Peptides and Proteins - genetics ; Italy ; Male ; Medical sciences ; Microbiology ; Mycobacteriology and Aerobic Actinomycetes ; Mycobacterium avium subsp. paratuberculosis - isolation & purification ; Nod2 Signaling Adaptor Protein ; Paratuberculosis - complications ; Paratuberculosis - epidemiology ; Paratuberculosis - microbiology</subject><ispartof>Journal of Clinical Microbiology, 2005-10, Vol.43 (10), p.5275-5277</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright © 2005, American Society for Microbiology 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c530t-749ec8ec94432ac893c7ddf0dbf772b7e9930472316f87f5743feb3afda7d57e3</citedby><cites>FETCH-LOGICAL-c530t-749ec8ec94432ac893c7ddf0dbf772b7e9930472316f87f5743feb3afda7d57e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1248481/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1248481/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,3174,3175,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17175324$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16207995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sechi, Leonardo A</creatorcontrib><creatorcontrib>Gazouli, Maria</creatorcontrib><creatorcontrib>Ikonomopoulos, John</creatorcontrib><creatorcontrib>Lukas, John C</creatorcontrib><creatorcontrib>Scanu, Antonio M</creatorcontrib><creatorcontrib>Ahmed, Niyaz</creatorcontrib><creatorcontrib>Fadda, Giovanni</creatorcontrib><creatorcontrib>Zanetti, Stefania</creatorcontrib><title>Mycobacterium avium subsp. paratuberculosis, Genetic Susceptibility to Crohn's Disease, and Sardinians: the Way Ahead</title><title>Journal of Clinical Microbiology</title><addtitle>J Clin Microbiol</addtitle><description>Thepresent study was performed to determine what proportion of people inSardinia with or without Crohn's disease were infected withMycobacterium avium subspecies paratuberculosis andhad a preponderance of allelic variants of Nod2, an intracellularprotein involved in Crohn's disease susceptibility. 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Psychology</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Intracellular Signaling Peptides and Proteins - genetics</subject><subject>Italy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Mycobacteriology and Aerobic Actinomycetes</subject><subject>Mycobacterium avium subsp. paratuberculosis - isolation & purification</subject><subject>Nod2 Signaling Adaptor Protein</subject><subject>Paratuberculosis - complications</subject><subject>Paratuberculosis - epidemiology</subject><subject>Paratuberculosis - microbiology</subject><issn>0095-1137</issn><issn>1098-660X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqFkU1v1DAQhiMEokvhL4CFBFyaxZ-ZhANStUABteKwVHCzJo6zcZUv7KRo_z2OdkXLics7Gs0zrz16k4QwumaM52-_bq7WUqxjqzioNAqsOaXqQbJitMjTLKM_HyYrSguVMibgJHkSwg2lTEqlHicnLOMUikKtkvlqb4YSzWS9mzuCt4uGuQzjmozocZpL683cDsGFM3Jhezs5Q7ZzMHacXOlaN-3JNJCNH5r-TSAfXLAY7BnBviJb9JXrHfbhHZkaS37gnpw3FqunyaMa22CfHetpcv3p4_fN5_Ty28WXzfllapSgUwqysCa3ppBScDR5IQxUVU2rsgbgJdiiEFQCFyyrc6gVSFHbUmBdIVQKrDhN3h98x7nsbGVsP3ls9ehdh36vB3T630nvGr0bbjXjMpc5iwavjwZ--DXbMOnOxdPbFns7zEFneZYxBfBfkEGmICtoBPMDaPwQgrf1398wqpdwdQxXS7G0S7iLgF7CjavP719zt3hMMwKvjgAGg23tsTcu3HHAQAkuI_fywDVu1_x23moMnb4x3b13I_TiANU4aNz5aHS95ZQJymg04Vz8AXKLxJg</recordid><startdate>20051001</startdate><enddate>20051001</enddate><creator>Sechi, Leonardo A</creator><creator>Gazouli, Maria</creator><creator>Ikonomopoulos, John</creator><creator>Lukas, John C</creator><creator>Scanu, Antonio M</creator><creator>Ahmed, Niyaz</creator><creator>Fadda, Giovanni</creator><creator>Zanetti, Stefania</creator><general>American Society for Microbiology</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20051001</creationdate><title>Mycobacterium avium subsp. paratuberculosis, Genetic Susceptibility to Crohn's Disease, and Sardinians: the Way Ahead</title><author>Sechi, Leonardo A ; Gazouli, Maria ; Ikonomopoulos, John ; Lukas, John C ; Scanu, Antonio M ; Ahmed, Niyaz ; Fadda, Giovanni ; Zanetti, Stefania</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c530t-749ec8ec94432ac893c7ddf0dbf772b7e9930472316f87f5743feb3afda7d57e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biological and medical sciences</topic><topic>Crohn Disease - epidemiology</topic><topic>Crohn Disease - etiology</topic><topic>Crohn Disease - genetics</topic><topic>Crohn Disease - microbiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Intracellular Signaling Peptides and Proteins - genetics</topic><topic>Italy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Mycobacteriology and Aerobic Actinomycetes</topic><topic>Mycobacterium avium subsp. paratuberculosis - isolation & purification</topic><topic>Nod2 Signaling Adaptor Protein</topic><topic>Paratuberculosis - complications</topic><topic>Paratuberculosis - epidemiology</topic><topic>Paratuberculosis - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sechi, Leonardo A</creatorcontrib><creatorcontrib>Gazouli, Maria</creatorcontrib><creatorcontrib>Ikonomopoulos, John</creatorcontrib><creatorcontrib>Lukas, John C</creatorcontrib><creatorcontrib>Scanu, Antonio M</creatorcontrib><creatorcontrib>Ahmed, Niyaz</creatorcontrib><creatorcontrib>Fadda, Giovanni</creatorcontrib><creatorcontrib>Zanetti, Stefania</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Clinical Microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sechi, Leonardo A</au><au>Gazouli, Maria</au><au>Ikonomopoulos, John</au><au>Lukas, John C</au><au>Scanu, Antonio M</au><au>Ahmed, Niyaz</au><au>Fadda, Giovanni</au><au>Zanetti, Stefania</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mycobacterium avium subsp. paratuberculosis, Genetic Susceptibility to Crohn's Disease, and Sardinians: the Way Ahead</atitle><jtitle>Journal of Clinical Microbiology</jtitle><addtitle>J Clin Microbiol</addtitle><date>2005-10-01</date><risdate>2005</risdate><volume>43</volume><issue>10</issue><spage>5275</spage><epage>5277</epage><pages>5275-5277</pages><issn>0095-1137</issn><eissn>1098-660X</eissn><coden>JCMIDW</coden><abstract>Thepresent study was performed to determine what proportion of people inSardinia with or without Crohn's disease were infected withMycobacterium avium subspecies paratuberculosis andhad a preponderance of allelic variants of Nod2, an intracellularprotein involved in Crohn's disease susceptibility. 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| source | American Society for Microbiology Journals; PubMed Central |
| subjects | Biological and medical sciences Crohn Disease - epidemiology Crohn Disease - etiology Crohn Disease - genetics Crohn Disease - microbiology Female Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease Humans Infectious diseases Intracellular Signaling Peptides and Proteins - genetics Italy Male Medical sciences Microbiology Mycobacteriology and Aerobic Actinomycetes Mycobacterium avium subsp. paratuberculosis - isolation & purification Nod2 Signaling Adaptor Protein Paratuberculosis - complications Paratuberculosis - epidemiology Paratuberculosis - microbiology |
| title | Mycobacterium avium subsp. paratuberculosis, Genetic Susceptibility to Crohn's Disease, and Sardinians: the Way Ahead |
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