Toll-Like Receptor 2 Deficiency Delays Pneumococcal Phagocytosis and Impairs Oxidative Killing by Granulocytes

Phagocytosis and killing of Streptococcus pneumoniae was compared in blood-derived wild-type (WT) and Toll-like receptor 2 (TLR2)-deficient (TLR2[superscript -/-]) polymorphonuclear leukocytes (PMN). Phagocytosis of green fluorescent protein-transformed pneumococci was delayed in TLR2[superscript -/...

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Bibliographic Details
Published in:Infection and Immunity 2005-12, Vol.73 (12), p.8397-8401
Main Authors: Letiembre, Maryse, Echchannaoui, Hakim, Bachmann, Philipp, Ferracin, Fabrizia, Nieto, Concepción, Espinosa, Manuel, Landmann, Regine
Format: Article
Language:English
Subjects:
Animals
Bacteriology
Biological and medical sciences
Cells, Cultured
Fundamental and applied biological sciences. Psychology
Granulocytes - chemistry
Granulocytes - immunology
Granulocytes - microbiology
Green Fluorescent Proteins - analysis
Host Response and Inflammation
Mice
Mice, Knockout
Microbiology
Miscellaneous
Oxidation-Reduction
Phagocytosis - genetics
Streptococcus pneumoniae
Streptococcus pneumoniae - immunology
Toll-Like Receptor 2 - deficiency
Toll-Like Receptor 2 - genetics
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Summary:Phagocytosis and killing of Streptococcus pneumoniae was compared in blood-derived wild-type (WT) and Toll-like receptor 2 (TLR2)-deficient (TLR2[superscript -/-]) polymorphonuclear leukocytes (PMN). Phagocytosis of green fluorescent protein-transformed pneumococci was delayed in TLR2[superscript -/-] PMN. These cells exhibited also a lower oxidative bactericidal activity against S. pneumoniae than WT PMN, suggesting that TLR2 modulates bacterial clearance in PMN.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.73.12.8397-8401.2005