Emergence of a Clinical Daptomycin-Resistant Staphylococcus aureus Isolate during Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia and Osteomyelitis

The emergence of a clinically daptomycin-resistant Staphylococcus aureus isolate occurred during treatment of methicillin-resistant S. aureus bacteremia and probable vertebral osteomyelitis. The breakthrough isolate was indistinguishable from pretreatment daptomycin-susceptible isolates by pulsed-fi...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2006-02, Vol.44 (2), p.595-597
Main Authors: Marty, Francisco M, Yeh, Wendy W, Wennersten, Christine B, Venkataraman, Lata, Albano, Esperanza, Alyea, Edwin P, Gold, Howard S, Baden, Lindsey R, Pillai, Satish K
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Bacteremia - drug therapy
Bacteremia - microbiology
Bacterial diseases
Bacterial sepsis
Bacteriology
Biological and medical sciences
Daptomycin - pharmacology
Daptomycin - therapeutic use
Drug Resistance, Bacterial
Electrophoresis, Gel, Pulsed-Field
Fundamental and applied biological sciences. Psychology
Human bacterial diseases
Humans
Infectious diseases
Male
Medical sciences
Methicillin Resistance
Microbial Sensitivity Tests
Microbiology
Middle Aged
Miscellaneous
Osteomyelitis - drug therapy
Osteomyelitis - microbiology
Staphylococcal Infections - drug therapy
Staphylococcal Infections - microbiology
Staphylococcus aureus
Staphylococcus aureus - classification
Staphylococcus aureus - drug effects
Staphylococcus aureus - genetics
Staphylococcus aureus - isolation & purification
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Summary:The emergence of a clinically daptomycin-resistant Staphylococcus aureus isolate occurred during treatment of methicillin-resistant S. aureus bacteremia and probable vertebral osteomyelitis. The breakthrough isolate was indistinguishable from pretreatment daptomycin-susceptible isolates by pulsed-field gel electrophoresis. Daptomycin nonsusceptibility was confirmed by MIC and time-kill curve analyses.
ISSN:0095-1137
1098-660X
1098-5530
DOI:10.1128/JCM.44.2.595-597.2006