Distribution of hsp65 PCR-Restriction Enzyme Analysis Patterns among Mycobacterium avium Complex Isolates in Thailand

A total of 227 clinical Mycobacterium avium complex isolates from Thailand were differentiated into species and types by using PCR-restriction enzyme analysis of hsp65. The distribution of types showed the predominance of M. avium I (77%) in blood specimens, whereas M. intracellulare I was more comm...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2006-10, Vol.44 (10), p.3819-3821
Main Authors: Prammananan, Therdsak, Phunpruch, Saranya, Tingtoy, Nipa, Srimuang, Somboon, Chaiprasert, Angkana
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Bacterial Proteins - metabolism
Biological and medical sciences
Chaperonin 60
Chaperonins - metabolism
Child
Child, Preschool
Female
Fundamental and applied biological sciences. Psychology
Humans
Infectious diseases
Male
Medical sciences
Microbiology
Middle Aged
Mycobacteriology and Aerobic Actinomycetes
Mycobacterium avium
Mycobacterium avium Complex - genetics
Mycobacterium avium-intracellulare Infection - epidemiology
Mycobacterium avium-intracellulare Infection - microbiology
Polymerase Chain Reaction - methods
Restriction Mapping - methods
Thailand - epidemiology
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Summary:A total of 227 clinical Mycobacterium avium complex isolates from Thailand were differentiated into species and types by using PCR-restriction enzyme analysis of hsp65. The distribution of types showed the predominance of M. avium I (77%) in blood specimens, whereas M. intracellulare I was more commonly found in pulmonary specimens (44.2%). In addition, infections with M. avium were more likely to be found in younger adults (20 to 39 years old), while infections with M. intracellulare were more likely to be found in older adults (>=60 years old). Our results provide the useful epidemiological information that some particular types have more invasive and virulent characters than others.
ISSN:0095-1137
1098-660X
1098-5530
DOI:10.1128/JCM.02495-05