Curcacycline B, a cyclic nonapeptide from Jatropha curcas enhancing rotamase activity of cyclophilin

The structure of curcacycline B (1), a cyclic nonapeptide isolated from Jatropha curcas latex was elucidated by combination of chemical degradation, LSIMS data and 2D NMR experiments. Curcacycline B was shown to enhance the rotamase activity of human cyclophilin B.

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Bibliographic Details
Published in:Tetrahedron letters 1997, Vol.38 (16), p.3845-3848
Main Authors: Auvin, C, Baraguey, C, Blond, A, Lezenven, F, Pousset, J.L, Bodo, B
Format: Article
Language:English
Subjects:
chemical structure
cyclic peptides
Online Access:Get full text
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Summary:The structure of curcacycline B (1), a cyclic nonapeptide isolated from Jatropha curcas latex was elucidated by combination of chemical degradation, LSIMS data and 2D NMR experiments. Curcacycline B was shown to enhance the rotamase activity of human cyclophilin B.
ISSN:0040-4039
1873-3581