Escherichia coli Constructs Expressing Human or Porcine Enterotoxins Induce Identical Diarrheal Diseases in a Piglet Infection Model

To develop a piglet model for studying diarrheal disease and developing vaccines, we challenged gnotobiotic piglets with isogenic Escherichia coli strains constructed to express porcine 987P(F6) fimbriae and a heat-labile or a heat-stable enterotoxin to examine clinical outcomes. Piglets developed i...

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Bibliographic Details
Published in:Applied and Environmental Microbiology 2008-09, Vol.74 (18), p.5832-5837
Main Authors: Zhang, Weiping, Robertson, Donald C, Zhang, Chengxian, Bai, Wei, Zhao, Mojun, Francis, David H
Format: Article
Language:English
Subjects:
Animal models
Animals
Bacterial Toxins - biosynthesis
Bacterial Toxins - genetics
Biological and medical sciences
Diarrhea - microbiology
Diarrhea - veterinary
Enterotoxigenic Escherichia coli - genetics
Enterotoxigenic Escherichia coli - metabolism
Enterotoxigenic Escherichia coli - pathogenicity
Enterotoxins - biosynthesis
Enterotoxins - genetics
Escherichia coli
Escherichia coli Infections - microbiology
Escherichia coli Infections - veterinary
Escherichia coli Proteins - biosynthesis
Escherichia coli Proteins - genetics
Fimbriae, Bacterial - genetics
Fundamental and applied biological sciences. Psychology
Gene Expression
Genes, Bacterial
Germ-Free Life
Host-Pathogen Interactions
Humans
Microbiology
Models, Animal
Plasmids
Public Health Microbiology
Swine - microbiology
Swine Diseases - microbiology
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Summary:To develop a piglet model for studying diarrheal disease and developing vaccines, we challenged gnotobiotic piglets with isogenic Escherichia coli strains constructed to express porcine 987P(F6) fimbriae and a heat-labile or a heat-stable enterotoxin to examine clinical outcomes. Piglets developed identical diarrheal diseases when inoculated with constructs expressing human or porcine enterotoxins.
ISSN:0099-2240
1098-5336
1098-6596
DOI:10.1128/AEM.00893-08