Phospholipase Cβ3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain

Treatment of neuropathic pain is a major clinical problem. This study shows expression of phospholipase ss3 (PLCss3) in mouse and human DRG neurons, mainly in small ones and mostly with a nonpeptidergic phenotype. After spared nerve injury, the pain threshold was strongly reduced, and systemic treat...

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Published in:Proceedings of the National Academy of Sciences - PNAS 2008-12, Vol.105 (50), p.20004-20008
Main Authors: Shi, Tie-Jun Sten, Liu, Su-Xing Leslie, Hammarberg, Henrik, Watanabe, Masahiko, Xu, Zhi-Qing David, Hökfelt, Tomas
Format: Article
Language:English
Subjects:
Antiserum
Behavioral neuroscience
Biological Sciences
Humans
Hyperalgesia
Nervous system trauma
Neurons
Pain
Receptors
Spinal cord
Spinal ganglia
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cited_by cdi_FETCH-LOGICAL-c4615-12abc51ed6ebde16b826a9a8b058664dbfe47af68a71f27c1f9b96c5595608753
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container_title Proceedings of the National Academy of Sciences - PNAS
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creator Shi, Tie-Jun Sten
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description Treatment of neuropathic pain is a major clinical problem. This study shows expression of phospholipase ss3 (PLCss3) in mouse and human DRG neurons, mainly in small ones and mostly with a nonpeptidergic phenotype. After spared nerve injury, the pain threshold was strongly reduced, and systemic treatment of such animals with the unselective PLC inhibitor U73122 caused a rapid and long-lasting (48-h) increase in pain threshold. Thus, inhibition of PLC may provide a way to treat neuropathic pain.
doi_str_mv 10.1073/pnas.0810899105
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subjects Antiserum
Behavioral neuroscience
Biological Sciences
Humans
Hyperalgesia
Nervous system trauma
Neurons
Pain
Receptors
Spinal cord
Spinal ganglia
title Phospholipase Cβ3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain
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