New Components from Silybum marianum L. Fruits: A Theory Comes True

The fruits of Silybum marianum L. (milk thistle) has been used for the treatment of hepatic and biliary diseases since ancient times. As separation techniques improved several isomers of silybin--the first determined active compound of milk thistle--have been described. Moreover, a new variety, the...

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Bibliographic Details
Published in:Chromatographia 2008, Vol.68 (1), p.5-11
Main Authors: Nyiredy, Szabolcs, Szűcs, Zoltán, Antus, Sándor, Samu, Zsuzsanna
Format: Article
Language:English
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Summary:The fruits of Silybum marianum L. (milk thistle) has been used for the treatment of hepatic and biliary diseases since ancient times. As separation techniques improved several isomers of silybin--the first determined active compound of milk thistle--have been described. Moreover, a new variety, the white-flowered S. marianum was discovered which contains deoxy-derivatives of some of the flavanolignans found in the purple-flowered variety. Based on this observation Nyiredy presumed that the deoxy-derivatives of all known flavanolignans of the purple-flowered variety are present in the white-flowered one. To prove this prediction several separations have been developed by the use of “PRISMA” principle.
ISSN:0009-5893
1612-1112
DOI:10.1365/s10337-008-0722-3