Variations in Ceftazidime and Amoxicillin-Clavulanate Susceptibilities within a Clonal Infection of Burkholderia pseudomallei

A patient with a clonal infection of Burkholderia pseudomallei had subpopulations with ceftazidime and amoxicillin-clavulanate susceptibilities that differed among the clinical specimens. Resistance was associated with a novel Cys69Tyr substitution in the Ambler class A β-lactamase. Susceptibility t...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2009-05, Vol.47 (5), p.1556-1558
Main Authors: Sam, I. Ching, See, Kah Heng, Puthucheary, Savithri D
Format: Article
Language:English
Subjects:
Amino Acid Substitution
Amoxicillin-Potassium Clavulanate Combination - pharmacology
Anti-Bacterial Agents - pharmacology
Bacterial Proteins - genetics
Bacteriology
beta-Lactamases - genetics
Burkholderia pseudomallei
Burkholderia pseudomallei - drug effects
Burkholderia pseudomallei - isolation & purification
Ceftazidime - pharmacology
DNA, Bacterial - chemistry
DNA, Bacterial - genetics
Humans
Male
Melioidosis - microbiology
Microbial Sensitivity Tests
Middle Aged
Molecular Sequence Data
Mutation, Missense
Sequence Analysis, DNA
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Summary:A patient with a clonal infection of Burkholderia pseudomallei had subpopulations with ceftazidime and amoxicillin-clavulanate susceptibilities that differed among the clinical specimens. Resistance was associated with a novel Cys69Tyr substitution in the Ambler class A β-lactamase. Susceptibility testing of multiple colony variants from different sites should be performed for patients with culture-confirmed melioidosis.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.01657-08