Parvovirus B19 Infection Localized in the Intestinal Mucosa and Associated with Severe Inflammatory Bowel Disease

Infection by human parvovirus B19 is widespread and can be associated with a wide range of different pathologies and clinical manifestations. We provide the first evidence of localization of an active parvovirus B19 infection in the intestinal mucosa and its association with a severe inflammatory bo...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2009-05, Vol.47 (5), p.1591-1595
Main Authors: Pironi, Loris, Bonvicini, Francesca, Gionchetti, Paolo, D'Errico, Antonia, Rizzello, Fernando, Corsini, Catia, Foroni, Laura, Gallinella, Giorgio
Format: Article
Language:English
Subjects:
Biological and medical sciences
Case Reports
Colon - pathology
Duodenum - pathology
Fundamental and applied biological sciences. Psychology
Human parvovirus B19
Human viral diseases
Humans
Infectious diseases
Inflammation - pathology
Inflammatory Bowel Diseases - complications
Intestinal Mucosa - pathology
Intestinal Mucosa - virology
Male
Medical sciences
Microbiology
Middle Aged
Parvoviridae Infections - complications
Parvoviridae Infections - pathology
Parvoviridae Infections - virology
Parvovirus B19, Human - isolation & purification
T-Lymphocytes - virology
Viral diseases
Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
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Summary:Infection by human parvovirus B19 is widespread and can be associated with a wide range of different pathologies and clinical manifestations. We provide the first evidence of localization of an active parvovirus B19 infection in the intestinal mucosa and its association with a severe inflammatory bowel disease, characterized by duodenal villous atrophy with increased intraepithelial lymphocytes and inflammatory infiltrates in the colonic mucosa. Virus in the intestinal mucosa was detected in cells of the inflammatory infiltrate, identified as T lymphocytes and selectively localized in sites of active tissue degeneration.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.00706-08