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Parvovirus B19 Infection Localized in the Intestinal Mucosa and Associated with Severe Inflammatory Bowel Disease
Infection by human parvovirus B19 is widespread and can be associated with a wide range of different pathologies and clinical manifestations. We provide the first evidence of localization of an active parvovirus B19 infection in the intestinal mucosa and its association with a severe inflammatory bo...
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| Published in: | Journal of Clinical Microbiology 2009-05, Vol.47 (5), p.1591-1595 |
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| Main Authors: | , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c493t-b7e7e98e52e773a0120ee2cbaf9a4d916769f0e6cbe76062697081e3056f1dd03 |
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| cites | cdi_FETCH-LOGICAL-c493t-b7e7e98e52e773a0120ee2cbaf9a4d916769f0e6cbe76062697081e3056f1dd03 |
| container_end_page | 1595 |
| container_issue | 5 |
| container_start_page | 1591 |
| container_title | Journal of Clinical Microbiology |
| container_volume | 47 |
| creator | Pironi, Loris Bonvicini, Francesca Gionchetti, Paolo D'Errico, Antonia Rizzello, Fernando Corsini, Catia Foroni, Laura Gallinella, Giorgio |
| description | Infection by human parvovirus B19 is widespread and can be associated with a wide range of different pathologies and clinical manifestations. We provide the first evidence of localization of an active parvovirus B19 infection in the intestinal mucosa and its association with a severe inflammatory bowel disease, characterized by duodenal villous atrophy with increased intraepithelial lymphocytes and inflammatory infiltrates in the colonic mucosa. Virus in the intestinal mucosa was detected in cells of the inflammatory infiltrate, identified as T lymphocytes and selectively localized in sites of active tissue degeneration. |
| doi_str_mv | 10.1128/JCM.00706-08 |
| format | article |
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We provide the first evidence of localization of an active parvovirus B19 infection in the intestinal mucosa and its association with a severe inflammatory bowel disease, characterized by duodenal villous atrophy with increased intraepithelial lymphocytes and inflammatory infiltrates in the colonic mucosa. Virus in the intestinal mucosa was detected in cells of the inflammatory infiltrate, identified as T lymphocytes and selectively localized in sites of active tissue degeneration.</description><identifier>ISSN: 0095-1137</identifier><identifier>EISSN: 1098-660X</identifier><identifier>DOI: 10.1128/JCM.00706-08</identifier><identifier>PMID: 19279179</identifier><identifier>CODEN: JCMIDW</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Biological and medical sciences ; Case Reports ; Colon - pathology ; Duodenum - pathology ; Fundamental and applied biological sciences. Psychology ; Human parvovirus B19 ; Human viral diseases ; Humans ; Infectious diseases ; Inflammation - pathology ; Inflammatory Bowel Diseases - complications ; Intestinal Mucosa - pathology ; Intestinal Mucosa - virology ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Parvoviridae Infections - complications ; Parvoviridae Infections - pathology ; Parvoviridae Infections - virology ; Parvovirus B19, Human - isolation & purification ; T-Lymphocytes - virology ; Viral diseases ; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</subject><ispartof>Journal of Clinical Microbiology, 2009-05, Vol.47 (5), p.1591-1595</ispartof><rights>2009 INIST-CNRS</rights><rights>Copyright © 2009, American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-b7e7e98e52e773a0120ee2cbaf9a4d916769f0e6cbe76062697081e3056f1dd03</citedby><cites>FETCH-LOGICAL-c493t-b7e7e98e52e773a0120ee2cbaf9a4d916769f0e6cbe76062697081e3056f1dd03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681858/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681858/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,3186,3187,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21464815$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19279179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pironi, Loris</creatorcontrib><creatorcontrib>Bonvicini, Francesca</creatorcontrib><creatorcontrib>Gionchetti, Paolo</creatorcontrib><creatorcontrib>D'Errico, Antonia</creatorcontrib><creatorcontrib>Rizzello, Fernando</creatorcontrib><creatorcontrib>Corsini, Catia</creatorcontrib><creatorcontrib>Foroni, Laura</creatorcontrib><creatorcontrib>Gallinella, Giorgio</creatorcontrib><title>Parvovirus B19 Infection Localized in the Intestinal Mucosa and Associated with Severe Inflammatory Bowel Disease</title><title>Journal of Clinical Microbiology</title><addtitle>J Clin Microbiol</addtitle><description>Infection by human parvovirus B19 is widespread and can be associated with a wide range of different pathologies and clinical manifestations. We provide the first evidence of localization of an active parvovirus B19 infection in the intestinal mucosa and its association with a severe inflammatory bowel disease, characterized by duodenal villous atrophy with increased intraepithelial lymphocytes and inflammatory infiltrates in the colonic mucosa. Virus in the intestinal mucosa was detected in cells of the inflammatory infiltrate, identified as T lymphocytes and selectively localized in sites of active tissue degeneration.</description><subject>Biological and medical sciences</subject><subject>Case Reports</subject><subject>Colon - pathology</subject><subject>Duodenum - pathology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human parvovirus B19</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Inflammation - pathology</subject><subject>Inflammatory Bowel Diseases - complications</subject><subject>Intestinal Mucosa - pathology</subject><subject>Intestinal Mucosa - virology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Parvoviridae Infections - complications</subject><subject>Parvoviridae Infections - pathology</subject><subject>Parvoviridae Infections - virology</subject><subject>Parvovirus B19, Human - isolation & purification</subject><subject>T-Lymphocytes - virology</subject><subject>Viral diseases</subject><subject>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</subject><issn>0095-1137</issn><issn>1098-660X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqF0U1v1DAQBuAIgehSuHEGc6AnUmacxI4vSO2Wj6KtQCqVuFleZ7LrKolbO7ur8uvxdlcFTpzmMI9ezejNspcIx4i8fv91enEMIEHkUD_KJgiqzoWAn4-zCYCqcsRCHmTPYrwGwLKsqqfZASouFUo1yW6_m7D2axdWkZ2iYudDS3Z0fmAzb03nflHD3MDGJaXVSHF0g-nYxcr6aJgZGnYSo7fOjMlt3Lhkl7SmsMVtZ_rejD7csVO_oY6duUgm0vPsSWu6SC_28zC7-vTxx_RLPvv2-Xx6MsttqYoxn0uSpGqqOElZGEAORNzOTatM2SgUUqgWSNg5SQGCCyWhRiqgEi02DRSH2Ydd7s1q3lNjaRiD6fRNcL0Jd9obp__dDG6pF36tuaixruoUcLQPCP52lV7XvYuWus4M5FdRC4kKeCH-CzkWoBRsE9_toA0-xkDtwzUIelumTmXq-zL1PX_19wd_8L69BN7ugYmprDaYwbr44DiWoqyxSu7Nzi3dYrlxgbSJvb62vS6lrjRWCpN5vTOt8dosQsq5uuSQTkfBq6LixW__ubzO</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Pironi, Loris</creator><creator>Bonvicini, Francesca</creator><creator>Gionchetti, Paolo</creator><creator>D'Errico, Antonia</creator><creator>Rizzello, Fernando</creator><creator>Corsini, Catia</creator><creator>Foroni, Laura</creator><creator>Gallinella, Giorgio</creator><general>American Society for Microbiology</general><general>American Society for Microbiology (ASM)</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090501</creationdate><title>Parvovirus B19 Infection Localized in the Intestinal Mucosa and Associated with Severe Inflammatory Bowel Disease</title><author>Pironi, Loris ; Bonvicini, Francesca ; Gionchetti, Paolo ; D'Errico, Antonia ; Rizzello, Fernando ; Corsini, Catia ; Foroni, Laura ; Gallinella, Giorgio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-b7e7e98e52e773a0120ee2cbaf9a4d916769f0e6cbe76062697081e3056f1dd03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biological and medical sciences</topic><topic>Case Reports</topic><topic>Colon - pathology</topic><topic>Duodenum - pathology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human parvovirus B19</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Inflammation - pathology</topic><topic>Inflammatory Bowel Diseases - complications</topic><topic>Intestinal Mucosa - pathology</topic><topic>Intestinal Mucosa - virology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Parvoviridae Infections - complications</topic><topic>Parvoviridae Infections - pathology</topic><topic>Parvoviridae Infections - virology</topic><topic>Parvovirus B19, Human - isolation & purification</topic><topic>T-Lymphocytes - virology</topic><topic>Viral diseases</topic><topic>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pironi, Loris</creatorcontrib><creatorcontrib>Bonvicini, Francesca</creatorcontrib><creatorcontrib>Gionchetti, Paolo</creatorcontrib><creatorcontrib>D'Errico, Antonia</creatorcontrib><creatorcontrib>Rizzello, Fernando</creatorcontrib><creatorcontrib>Corsini, Catia</creatorcontrib><creatorcontrib>Foroni, Laura</creatorcontrib><creatorcontrib>Gallinella, Giorgio</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Clinical Microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pironi, Loris</au><au>Bonvicini, Francesca</au><au>Gionchetti, Paolo</au><au>D'Errico, Antonia</au><au>Rizzello, Fernando</au><au>Corsini, Catia</au><au>Foroni, Laura</au><au>Gallinella, Giorgio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parvovirus B19 Infection Localized in the Intestinal Mucosa and Associated with Severe Inflammatory Bowel Disease</atitle><jtitle>Journal of Clinical Microbiology</jtitle><addtitle>J Clin Microbiol</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>47</volume><issue>5</issue><spage>1591</spage><epage>1595</epage><pages>1591-1595</pages><issn>0095-1137</issn><eissn>1098-660X</eissn><coden>JCMIDW</coden><abstract>Infection by human parvovirus B19 is widespread and can be associated with a wide range of different pathologies and clinical manifestations. We provide the first evidence of localization of an active parvovirus B19 infection in the intestinal mucosa and its association with a severe inflammatory bowel disease, characterized by duodenal villous atrophy with increased intraepithelial lymphocytes and inflammatory infiltrates in the colonic mucosa. Virus in the intestinal mucosa was detected in cells of the inflammatory infiltrate, identified as T lymphocytes and selectively localized in sites of active tissue degeneration.</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>19279179</pmid><doi>10.1128/JCM.00706-08</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0095-1137 |
| ispartof | Journal of Clinical Microbiology, 2009-05, Vol.47 (5), p.1591-1595 |
| issn | 0095-1137 1098-660X |
| language | eng |
| recordid | cdi_fao_agris_US201301625352 |
| source | American Society for Microbiology美国微生物学会全文期刊; PubMed |
| subjects | Biological and medical sciences Case Reports Colon - pathology Duodenum - pathology Fundamental and applied biological sciences. Psychology Human parvovirus B19 Human viral diseases Humans Infectious diseases Inflammation - pathology Inflammatory Bowel Diseases - complications Intestinal Mucosa - pathology Intestinal Mucosa - virology Male Medical sciences Microbiology Middle Aged Parvoviridae Infections - complications Parvoviridae Infections - pathology Parvoviridae Infections - virology Parvovirus B19, Human - isolation & purification T-Lymphocytes - virology Viral diseases Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye |
| title | Parvovirus B19 Infection Localized in the Intestinal Mucosa and Associated with Severe Inflammatory Bowel Disease |
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