Association of FcRn Heavy Chain Encoding Gene (FCGRT) Polymorphisms with IgG Content in Bovine Colostrum

In this study, we evaluated haplotypes of the bovine FCGRT (encoding the FcRn heavy chain) and their relationship to the IgG concentration in bovine colostrum. Four single nucleotide polymorphism (SNP), classified into five haplotypes, were identified in a total of 49 Holstein-Frisians cows. Haploty...

Full description

Saved in:
Bibliographic Details
Published in:Animal biotechnology 2009-01, Vol.20 (1-4), p.242-246
Main Authors: Zhang, Ran, Zhao, Zhihui, Zhao, Yaofeng, Kacskovics, Imre, Eijk, Marjolein van der, Groot, Nanda de, Li, Ning, Hammarstrom, Lennart
Format: Article
Language:English
Subjects:
Alleles
Animals
Bovine colostrum
Cattle - genetics
Cattle - immunology
chemical composition
colostral immunity
Colostrum - chemistry
Colostrum - immunology
cow colostrum
dairy cows
FCGRT
genes
Haplotypes
Histocompatibility Antigens Class I - genetics
Histocompatibility Antigens Class I - immunology
Holstein
IgG concentration
immunoglobulin G
Immunoglobulin G - analysis
Immunoglobulin G - immunology
Medicin och hälsovetenskap
Polymorphism, Single Nucleotide
protein subunits
receptors
Receptors, Fc - genetics
Receptors, Fc - immunology
Single nucleotide polymorphism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this study, we evaluated haplotypes of the bovine FCGRT (encoding the FcRn heavy chain) and their relationship to the IgG concentration in bovine colostrum. Four single nucleotide polymorphism (SNP), classified into five haplotypes, were identified in a total of 49 Holstein-Frisians cows. Haplotype 5 was found to be significantly associated with a high IgG level ([OR] = 9.90, 95%CI = 1.11-88.34, p = 0.016) and haplotype 2 exhibited a similar trend ([OR] = 2.89, 95%CI = 1.17-7.11, p = 0.019).
ISSN:1049-5398
1532-2378
1532-2378
DOI:10.1080/10495390903196448