Label-free cellular manipulation and sorting via biocompatible ferrofluids

We present a simple microfluidic platform that uses biocompatible ferrofluids for the controlled manipulation and rapid separation of both microparticles and live cells. This low-cost platform exploits differences in particle size, shape, and elasticity to achieve rapid and efficient separation. Usi...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2009-12, Vol.106 (51), p.21478-21483
Main Authors: Kose, Ayse R, Fischer, Birgit, Mao, Leidong, Koser, Hur
Format: Article
Language:English
Subjects:
Bacteria
Biocompatibility
Biocompatible Materials
Biological Sciences
Cell Separation
Cells
Critical frequencies
Electric current
Electrodes
Erythrocytes
Ferrofluids
Fluids
Magnetic fields
Magnetics
Microfluidics - instrumentation
Nanoparticles
Nanotechnology
Particle Size
Physical Sciences
Sickles
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Summary:We present a simple microfluidic platform that uses biocompatible ferrofluids for the controlled manipulation and rapid separation of both microparticles and live cells. This low-cost platform exploits differences in particle size, shape, and elasticity to achieve rapid and efficient separation. Using microspheres, we demonstrate size-based separation with 99% separation efficiency and sub-10-μm resolution in
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0912138106