Effect of an Aqueous Extract of Olive (Olea europaea) Leaves on the Adrenal-Kidney-Pituitary Axis in Rats

A crude aqueous extract of the fresh leaves of olive (Olea europaea L., family Oleaceae) was administered orally for 14 consecutive days in doses of 100, 250, and 500 μg/kg body weight. The highest dose level tested caused a significant increase of ACTH (323.20 pg/mL), cortisol (1.29 pg/mL), and pot...

Full description

Saved in:
Bibliographic Details
Published in:Journal of herbs, spices & medicinal plants spices & medicinal plants, 2010-01, Vol.15 (4), p.352-360
Main Authors: ElMougy, S.A, Al-Qarawi, A.A, Bazaid, S.A
Format: Article
Language:English
Subjects:
ACTH
adrenal glands
aldosterone
animal models
Biological and medical sciences
biosynthesis
chemical constituents of plants
corticotropin
cortisol
dose response
enzyme activity
Fundamental and applied biological sciences. Psychology
leaves
Medical sciences
medicinal plants
medicinal properties
Olea europaea
olives
Pharmacology. Drug treatments
pituitary gland
plant extracts
quantitative analysis
rats
renal function
renin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A crude aqueous extract of the fresh leaves of olive (Olea europaea L., family Oleaceae) was administered orally for 14 consecutive days in doses of 100, 250, and 500 μg/kg body weight. The highest dose level tested caused a significant increase of ACTH (323.20 pg/mL), cortisol (1.29 pg/mL), and potassium (5.14 mEq/L) in the blood. In contrast, the renin (5.98 ng/mL/h), aldosterone (296.40 pg/mL), and sodium (127.80 mEq/L) concentrations in blood were significantly reduced at the same dose. The leaf extract exhibited activity in a dose-dependent manner.
ISSN:1049-6475
1540-3580
DOI:10.1080/10496470903507932