Results from the ARTEMIS DISK Global Antifungal Surveillance Study, 1997 to 2007: a 10.5-Year Analysis of Susceptibilities of Candida Species to Fluconazole and Voriconazole as Determined by CLSI Standardized Disk Diffusion

Fluconazole in vitro susceptibility test results for 256,882 isolates of Candida spp. were collected from 142 sites in 41 countries from June 1997 to December 2007. Data were collected for 197,619 isolates tested with voriconazole from 2001 to 2007. A total of 31 different species of Candida were is...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2010-04, Vol.48 (4), p.1366-1377
Main Authors: Pfaller, M.A, Diekema, D.J, Gibbs, D.L, Newell, V.A, Ellis, D, Tullio, V, Rodloff, A, Fu, W, Ling, T.A
Format: Article
Language:English
Subjects:
Antifungal Agents - pharmacology
Candida
Candida - classification
Candida - drug effects
Candida - isolation & purification
Candidiasis - microbiology
Fluconazole - pharmacology
Humans
Microbial Sensitivity Tests - methods
Mycology
Pyrimidines - pharmacology
Triazoles - pharmacology
Voriconazole
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Summary:Fluconazole in vitro susceptibility test results for 256,882 isolates of Candida spp. were collected from 142 sites in 41 countries from June 1997 to December 2007. Data were collected for 197,619 isolates tested with voriconazole from 2001 to 2007. A total of 31 different species of Candida were isolated. Increased rates of isolation of the common non-albicans species C. glabrata (10.2% to 11.7%), C. tropicalis (5.4% to 8.0%), and C. parapsilosis (4.8% to 5.6%) were noted when the time periods 1997 to 2000 and 2005 to 2007 were compared. Investigators tested clinical isolates of Candida spp. by the CLSI M44-A disk diffusion method. Overall, 90.2% of Candida isolates tested were susceptible (S) to fluconazole; however, 13 of 31 species identified exhibited decreased susceptibility (
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.02117-09