Evaluation of the migration of 15 photo-initiators from cardboard packaging into Tenax® using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)

Photo-initiators are widely used to cure ink on packaging materials used in food applications such as plastic films or cartonboards. In migration studies, food simulants are very often used to simulate food, like Tenax ®, which is the simulant for dry foodstuffs. In this paper a fast and reliable co...

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Bibliographic Details
Published in:Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment Chemistry, analysis, control, exposure & risk assessment, 2014-04, Vol.31 (4), p.767-775
Main Authors: Van Den Houwe, K, van de Velde, S, Evrard, C, Van Hoeck, E, Van Loco, J, Bolle, F
Format: Article
Language:English
Subjects:
acetonitrile
benzophenone
Biological and medical sciences
cardboard
Chromatography, Liquid - methods
Food additives
food contact material
Food contamination & poisoning
Food Contamination - analysis
Food industries
Food Packaging
foods
Fundamental and applied biological sciences. Psychology
Ink
liquid chromatography
Mass spectrometry
migration
Molecular Structure
packaging
packaging materials
paper and board
photo-initiators
Photosensitizing Agents
plastic film
Reproducibility of Results
tandem mass spectrometry
Tandem Mass Spectrometry - methods
Tenax
ultra-performance liquid chromatography
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Summary:Photo-initiators are widely used to cure ink on packaging materials used in food applications such as plastic films or cartonboards. In migration studies, food simulants are very often used to simulate food, like Tenax ®, which is the simulant for dry foodstuffs. In this paper a fast and reliable confirmation method for the determination of the following photo-initiators in Tenax ® is described: benzophenone (BP), 4,4´- bis (diethylamino)benzophenone (DEAB), 2-chloro-9H-thioxanthen-9-one (CTX), 1-chloro-4-propoxy-9H-thioxanthen-9-one (CPTX), 2,4-diethyl-9H-thioxanthen-9-one (DETX), 2,2-dimethoxy-2-phenyl acetophenone (DMPA), 4-(dimethylamino)benzophenone (DMBP), 2-ethylanthraquinone (EA), ethyl-4-dimethylaminobenzoate (EDMAB), 1-hydroxylcyclohexyl phenyl ketone (HCPK), 2-hydroxy-4´-(2-hydroxyethoxy)-2-methylpropiophenone (HMMP), 2-isopropyl-9H-thioxanthen-9-one (ITX), 4-methylbenzophenone (MBP), Michler’s ketone (MK), and 4-phenylbenzophenone (PBZ). After the migration study was completed, the simulant Tenax ® was extracted using acetonitrile, followed by analysis on ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Quantification was carried out using benzophenone-d ₁₀ (BP-d ₁₀) as internal standard. The presented method is validated in terms of matrix effect, specificity, linearity, recovery, precision and sensitivity, showing the method can detect all photo-initiators at very low concentrations (LOD 
ISSN:1944-0057
1944-0049
1944-0057
DOI:10.1080/19440049.2014.886340