Panuvéite hypertensive et dépigmentation cutanée chez un chien Montagne des Pyrénées

A Montagne des Pyrénées dog was presented for appearance changes of the left eye and facial mucocutaneous junction depigmentation. Physical examination revealed a hypertensive panuveitis and a mild facial vitiligo. The right eye, of which fundus was albinos, presented no abnormalities. The left eye...

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Bibliographic Details
Published in:Pratique médicale & chirurgicale de l'animal de compagnie 2011-07, Vol.46 (3-4), p.91-97
Main Authors: Dulaurent, T, Richard, J.-D, Regnier, A, Raymond, I, Delverdier, M, Cadiergues, M.-C
Format: Article
Language:fre
Subjects:
autoimmune diseases
biopsy
clinical examination
dogs
evisceration
histopathology
inflammation
melanization
melanocytes
nose
retina
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Summary:A Montagne des Pyrénées dog was presented for appearance changes of the left eye and facial mucocutaneous junction depigmentation. Physical examination revealed a hypertensive panuveitis and a mild facial vitiligo. The right eye, of which fundus was albinos, presented no abnormalities. The left eye was eviscerated. The product of the evisceration (uvea and retina) and biopsies of the mucocutaneous junction of the nasal region were routinely processed for histopathological examination. This confirmed the panuveitis and revealed focal absence of melanocytes along with minimal inflammation. The clinical and laboratory data matched with an immune-mediated disease against melanocytes. Although not confirmed, the hypothesis of uveodermatologic syndrome (Vogt-Koyanagi-Harada-like syndrome) remains possible.
ISSN:0758-1882
2212-5213
DOI:10.1016/j.anicom.2011.08.001