Three new flavonol glycosides from Suaeda maritima

• Published in: Journal of asian natural products research 2014-05, Vol.16 (5), p.434-439
• Main Authors: Abd El-Latif, Rasha R, Mansour, Ragaa M.A, Sharaf, Mohamed, Farag, Ahmad
• Format: Article
• Language: English
• Subjects: anticarcinogenic activity; Antineoplastic Agents, Phytogenic; biological study; Chenopodiaceae; Chenopodiaceae - chemistry; cytotoxicity; Drug Screening Assays, Antitumor; Female; flavonol polyglycosides; Flavonols - chemistry; Flavonols - isolation & purification; Flavonols - pharmacology; glycosides; Glycosides - chemistry; Glycosides - isolation & purification; Glycosides - pharmacology; HCT116 Cells; Hep G2 Cells; Humans; kaempferol; Molecular Structure; neoplasm cells; Nuclear Magnetic Resonance, Biomolecular; plant extracts; quercetin; spectroscopy; Stereoisomerism; Suaeda; Suaeda maritime
• ISSN: 1477-2213; 1028-6020; 1477-2213
• DOI: 10.1080/10286020.2014.902373

Three new flavonol glycosides isolated from the 70% methanol extract of Suaeda maritima (Chenopodiaceae) were characterized based on spectroscopic and chemical methods as quercetin 3- O -α- l -rhamnopyranosyl(1″′ → 6″)-β- d -galactopyranoside-7- O -β- d -glucopyranosyl(1″″′ → 2″″)-glucopyranoside, kaempferol 3- O -α- l -rhamnopyranosyl(1″′ → 6″)-β- d -galactopyranoside-7- O -β- d -glucopyranosyl(1″″′ → 2″″)-glucopyranoside, and kaempferol 3- O -α- l -rhamnopyranosyl(1″′ → 6″)-β- d -galactopyranoside-7- O -(2″″′- O - trans -feruloyl)-β- d -glucopyranosyl-(1″″′ → 2″″)-β- d -glucopyranoside. In addition, four known compounds, namely, quercetin and kaempferol, methyl cis , trans -ferulate, and methyl trans -ferulate were identified. The plant extract and these compounds showed cytotoxic activity against the human tumor cell lines MCF7, HCT116, and HEPG2.