new taraxastane-type triterpenoid glycoside from the roots of Clematis uncinata

A new taraxastane-type triterpenoid glycoside, clematiunicinoside I (1), together with four known ones (2–5), was isolated from the roots of Clematis uncinata . The structure of the new compound was elucidated on the basis of spectroscopic analyses and acid hydrolysis. The cytotoxic activities of al...

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Bibliographic Details
Published in:Journal of asian natural products research 2015-12, Vol.17 (12), p.1153-1159
Main Authors: Li, Shuo-Guo, Li, Man-Mei, Zhao, Bing-Xin, Wang, Ying, Ye, Wen-Cai
Format: Article
Language:English
Subjects:
acid hydrolysis
Clematis
Clematis - chemistry
Clematis uncinata
cytotoxicity
Drug Screening Assays, Antitumor
Female
glycosides
Glycosides - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
Humans
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Roots - chemistry
Ranunculaceae
roots
spectroscopy
taraxastane-type triterpenoid glycoside
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
triterpenoids
uterine cervical neoplasms
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Summary:A new taraxastane-type triterpenoid glycoside, clematiunicinoside I (1), together with four known ones (2–5), was isolated from the roots of Clematis uncinata . The structure of the new compound was elucidated on the basis of spectroscopic analyses and acid hydrolysis. The cytotoxic activities of all the compounds against caski cervical cancer (Caski) cells were evaluated. This is the first report of the presence of taraxastane-type triterpenoid glycoside in the genus Clematis .
ISSN:1477-2213
1028-6020
1477-2213
DOI:10.1080/10286020.2015.1117453