Human cortical sensorimotor network underlying feedback control of vocal pitch

The control of vocalization is critically dependent on auditory feedback. Here, we determined the human peri-Sylvian speech network that mediates feedback control of pitch using direct cortical recordings. Subjects phonated while a real-time signal processor briefly perturbed their output pitch (spe...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2013-02, Vol.110 (7), p.2653-2658
Main Authors: Chang, Edward F., Niziolek, Caroline A., Knight, Robert T., Nagarajan, Srikantan S., Houde, John F.
Format: Article
Language:English
Subjects:
Acoustic data
Acoustic Stimulation
Analysis of Variance
Animal vocalization
Auditory cortex
Behavioral neuroscience
Biological and medical sciences
Biological Sciences
Brain
Correlation analysis
Electrodes
Feedback control systems
Feedback, Sensory - physiology
Fundamental and applied biological sciences. Psychology
Hemispheres
Humans
Listening
Motor ability
Motor cortex
Motors
Phonation - physiology
Pitch Discrimination - physiology
Speech
Temporal Lobe - physiology
Time Factors
Vertebrates: nervous system and sense organs
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Summary:The control of vocalization is critically dependent on auditory feedback. Here, we determined the human peri-Sylvian speech network that mediates feedback control of pitch using direct cortical recordings. Subjects phonated while a real-time signal processor briefly perturbed their output pitch (speak condition). Subjects later heard the same recordings of their auditory feedback (listen condition). In posterior superior temporal gyrus, a proportion of sites had suppressed responses to normal feedback, whereas other spatially independent sites had enhanced responses to altered feedback. Behaviorally, speakers compensated for perturbations by changing their pitch. Single-trial analyses revealed that compensatory vocal changes were predicted by the magnitude of both auditory and subsequent ventral premotor responses to perturbations. Furthermore, sites whose responses to perturbation were enhanced in the speaking condition exhibited stronger correlations with behavior. This sensorimotor cortical network appears to underlie auditory feedback-based control of vocal pitch in humans.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1216827110