circadian oscillator gene GIGANTEA mediates a long-term response of the Arabidopsis thaliana circadian clock to sucrose

Circadian clocks are 24-h timing devices that phase cellular responses; coordinate growth, physiology, and metabolism; and anticipate the day-night cycle. Here we report sensitivity of the Arabidopsis thaliana circadian oscillator to sucrose, providing evidence that plant metabolism can regulate cir...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2011-03, Vol.108 (12), p.5104-5109
Main Authors: Dalchau, Neil, Baek, Seong J, Briggs, Helen M, Robertson, Fiona C, Dodd, Antony N, Gardner, Michael J, Stancombe, Matthew A, Haydon, Michael J, Stan, Guy-Bart, Gonçalves, Jorge M, Webb, Alex A.R
Format: Article
Language:English
Subjects:
Arabidopsis - genetics
Arabidopsis - metabolism
Arabidopsis Proteins - genetics
Arabidopsis Proteins - metabolism
Arabidopsis thaliana
Biological Sciences
Cells
Circadian Clocks - drug effects
Circadian Clocks - physiology
Circadian rhythm
Circadian Rhythm - drug effects
Circadian Rhythm - physiology
Circadian rhythms
Darkness
Data processing
Feedback
Flowers & plants
Gene expression
genes
Luminescence
Mathematical models
Messenger RNA
Metabolism
Modeling
Models, Biological
Oscillators
Parametric models
Plant growth regulators
Plants
prediction
Seedlings
Sucrose
Sucrose - metabolism
Sucrose - pharmacology
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Summary:Circadian clocks are 24-h timing devices that phase cellular responses; coordinate growth, physiology, and metabolism; and anticipate the day-night cycle. Here we report sensitivity of the Arabidopsis thaliana circadian oscillator to sucrose, providing evidence that plant metabolism can regulate circadian function. We found that the Arabidopsis circadian system is particularly sensitive to sucrose in the dark. These data suggest that there is a feedback between the molecular components that comprise the circadian oscillator and plant metabolism, with the circadian clock both regulating and being regulated by metabolism. We used also simulations within a three-loop mathematical model of the Arabidopsis circadian oscillator to identify components of the circadian clock sensitive to sucrose. The mathematical studies identified GIGANTEA (GI) as being associated with sucrose sensing. Experimental validation of this prediction demonstrated that GI is required for the full response of the circadian clock to sucrose. We demonstrate that GI acts as part of the sucrose-signaling network and propose this role permits metabolic input into circadian timing in ARABIDOPSIS:
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1015452108