Immediate-early transcription over covalently joined genome ends of bovine herpesvirus 1: the circ gene

Herpesvirus genomes are linear molecules in virions. Prior to replication in host cells, they form circular templates by unknown mechanisms. Examining lytic infection with bovine herpesvirus 1, we observed immediate-early transcription over joined genome ends, which suggested that circles are presen...

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Bibliographic Details
Published in:Journal of Virology 1993-03, Vol.67 (3), p.1328-1333
Main Authors: Fraefel, C. (University of Zurich, Zurich, Switzerland), Wirth, U.V, Vogt, B, Schwyzer, M
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
ARN MENSAJERO
ARN MESSAGER
Base Sequence
Biological and medical sciences
Cattle
Cells, Cultured
DNA, Circular - genetics
EXPRESION GENICA
EXPRESSION DES GENES
Fundamental and applied biological sciences. Psychology
GENE
GENES
Genes, Viral - genetics
Genetics
GENOMAS
GENOME
Genome, Viral
Herpesvirus 1, Bovine - genetics
Herpesvirus 3, Human - genetics
HERPESVIRUS BOVIN
HERPESVIRUS BOVINO
Microbiology
Molecular Sequence Data
Open Reading Frames - genetics
PROTEINAS
PROTEINE
Regulatory Sequences, Nucleic Acid - genetics
Repetitive Sequences, Nucleic Acid - genetics
RNA Precursors - genetics
RNA Precursors - metabolism
RNA Splicing - genetics
SECUENCIA NUCLEICA
Sequence Analysis, DNA
Sequence Homology, Amino Acid
SEQUENCE NUCLEIQUE
Transcription, Genetic
Virology
VIRUS DE LOS ANIMALES
VIRUS DES ANIMAUX
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Description
Summary:Herpesvirus genomes are linear molecules in virions. Prior to replication in host cells, they form circular templates by unknown mechanisms. Examining lytic infection with bovine herpesvirus 1, we observed immediate-early transcription over joined genome ends, which suggested that circles are present at the initial stage of infection. Among the transcripts was a spliced immediate-early RNA (1.5 kb) sharing exon 1 with previously described major immediate-early transcripts from the right genome end and exon 2 with a late transcript located near the left genome end. Exon 2 encodes a putative circ-encoded protein with homology to the varicella-zoster virus open reading frame 2 and equine herpesvirus 1 open reading frame 3 products. The novel features reported here for bovine herpesvirus 1 may constitute a more general property of herpesviruses
ISSN:0022-538X
1098-5514
DOI:10.1128/jvi.67.3.1328-1333.1993