Association of lysogenic bacteriophage MAV1 with virulence of Mycoplasma arthritidis

Mycoplasma arthritidis causes a severe polyarthritis under natural conditions in rats and under experimental conditions in both rats and mice. Although the disease itself has been extensively studied, M. arthritidis virulence factors remain uncharacterized. Comparison of relative arthritogenicity of...

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Bibliographic Details
Published in:Infection and Immunity 1995-10, Vol.63 (10), p.4016-4023
Main Authors: Voelker, L.L. (University of Alabama, Birmingham, Birmingham, AL.), Weaver, K.E, Ehle, L.J, Washburn, L.R
Format: Article
Language:English
Subjects:
Animals
Arthritis, Infectious - etiology
BACTERIOFAGOS
Bacteriology
BACTERIOPHAGE
Bacteriophages - genetics
Bacteriophages - pathogenicity
Biological and medical sciences
CHROMOSOME
CROMOSOMAS
DIFERENCIAS BIOLOGICAS
DIFFERENCE BIOLOGIQUE
DNA, Viral - analysis
Fundamental and applied biological sciences. Psychology
HIBRIDACION DE ADN
HYBRIDATION D'ADN
Lysogeny
Male
Microbiology
MYCOPLASMA
Mycoplasma - pathogenicity
Mycoplasma - virology
Mycoplasma arthritidis
Nucleic Acid Hybridization
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
PATOGENICIDAD
POUVOIR PATHOGENE
RAT
RATA
Rats
Rats, Inbred Lew
SECUENCIA NUCLEOTIDICA
SEQUENCE NUCLEOTIDIQUE
Virulence
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Description
Summary:Mycoplasma arthritidis causes a severe polyarthritis under natural conditions in rats and under experimental conditions in both rats and mice. Although the disease itself has been extensively studied, M. arthritidis virulence factors remain uncharacterized. Comparison of relative arthritogenicity of 20 strains of M. arthritidis revealed that the strains tended to fall into two groups, a highly arthritogenic group, inducing maximum arthritis scores of greater than or equal to 11 in rats, and a low-virulence group, inducing maximum scores of 6. Chromosomal DNA from the more highly arthritogenic strains possessed sequences that hybridized by Southern analysis with a probe prepared from lysogenic M. arthritidis bacteriophage MAV1, while DNA from low-virulence strains did not. One of the low-virulence strains, 158, was experimentally lysogenized with MAV1. Lysogenized 158 showed a significant increase in arthritogenicity over nonlysogenized 158. These data suggest that MAV1 carries a factor that is important in pathogenesis of M. arthritidis-induced arthritis of rats
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.63.10.4016-4023.1995