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Association of lysogenic bacteriophage MAV1 with virulence of Mycoplasma arthritidis
Mycoplasma arthritidis causes a severe polyarthritis under natural conditions in rats and under experimental conditions in both rats and mice. Although the disease itself has been extensively studied, M. arthritidis virulence factors remain uncharacterized. Comparison of relative arthritogenicity of...
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| Published in: | Infection and Immunity 1995-10, Vol.63 (10), p.4016-4023 |
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| container_end_page | 4023 |
| container_issue | 10 |
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| container_title | Infection and Immunity |
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| creator | Voelker, L.L. (University of Alabama, Birmingham, Birmingham, AL.) Weaver, K.E Ehle, L.J Washburn, L.R |
| description | Mycoplasma arthritidis causes a severe polyarthritis under natural conditions in rats and under experimental conditions in both rats and mice. Although the disease itself has been extensively studied, M. arthritidis virulence factors remain uncharacterized. Comparison of relative arthritogenicity of 20 strains of M. arthritidis revealed that the strains tended to fall into two groups, a highly arthritogenic group, inducing maximum arthritis scores of greater than or equal to 11 in rats, and a low-virulence group, inducing maximum scores of 6. Chromosomal DNA from the more highly arthritogenic strains possessed sequences that hybridized by Southern analysis with a probe prepared from lysogenic M. arthritidis bacteriophage MAV1, while DNA from low-virulence strains did not. One of the low-virulence strains, 158, was experimentally lysogenized with MAV1. Lysogenized 158 showed a significant increase in arthritogenicity over nonlysogenized 158. These data suggest that MAV1 carries a factor that is important in pathogenesis of M. arthritidis-induced arthritis of rats |
| doi_str_mv | 10.1128/IAI.63.10.4016-4023.1995 |
| format | article |
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(University of Alabama, Birmingham, Birmingham, AL.) ; Weaver, K.E ; Ehle, L.J ; Washburn, L.R</creator><creatorcontrib>Voelker, L.L. (University of Alabama, Birmingham, Birmingham, AL.) ; Weaver, K.E ; Ehle, L.J ; Washburn, L.R</creatorcontrib><description>Mycoplasma arthritidis causes a severe polyarthritis under natural conditions in rats and under experimental conditions in both rats and mice. Although the disease itself has been extensively studied, M. arthritidis virulence factors remain uncharacterized. Comparison of relative arthritogenicity of 20 strains of M. arthritidis revealed that the strains tended to fall into two groups, a highly arthritogenic group, inducing maximum arthritis scores of greater than or equal to 11 in rats, and a low-virulence group, inducing maximum scores of 6. Chromosomal DNA from the more highly arthritogenic strains possessed sequences that hybridized by Southern analysis with a probe prepared from lysogenic M. arthritidis bacteriophage MAV1, while DNA from low-virulence strains did not. One of the low-virulence strains, 158, was experimentally lysogenized with MAV1. Lysogenized 158 showed a significant increase in arthritogenicity over nonlysogenized 158. These data suggest that MAV1 carries a factor that is important in pathogenesis of M. arthritidis-induced arthritis of rats</description><identifier>ISSN: 0019-9567</identifier><identifier>EISSN: 1098-5522</identifier><identifier>DOI: 10.1128/IAI.63.10.4016-4023.1995</identifier><identifier>PMID: 7558313</identifier><identifier>CODEN: INFIBR</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Animals ; Arthritis, Infectious - etiology ; BACTERIOFAGOS ; Bacteriology ; BACTERIOPHAGE ; Bacteriophages - genetics ; Bacteriophages - pathogenicity ; Biological and medical sciences ; CHROMOSOME ; CROMOSOMAS ; DIFERENCIAS BIOLOGICAS ; DIFFERENCE BIOLOGIQUE ; DNA, Viral - analysis ; Fundamental and applied biological sciences. Psychology ; HIBRIDACION DE ADN ; HYBRIDATION D'ADN ; Lysogeny ; Male ; Microbiology ; MYCOPLASMA ; Mycoplasma - pathogenicity ; Mycoplasma - virology ; Mycoplasma arthritidis ; Nucleic Acid Hybridization ; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains ; PATOGENICIDAD ; POUVOIR PATHOGENE ; RAT ; RATA ; Rats ; Rats, Inbred Lew ; SECUENCIA NUCLEOTIDICA ; SEQUENCE NUCLEOTIDIQUE ; Virulence</subject><ispartof>Infection and Immunity, 1995-10, Vol.63 (10), p.4016-4023</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c520t-ad43882c3a957031d3a15579d1f8952d3f472a80b691a44399f945e3b84f8a993</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC173564/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC173564/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,3175,3176,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3668335$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7558313$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Voelker, L.L. (University of Alabama, Birmingham, Birmingham, AL.)</creatorcontrib><creatorcontrib>Weaver, K.E</creatorcontrib><creatorcontrib>Ehle, L.J</creatorcontrib><creatorcontrib>Washburn, L.R</creatorcontrib><title>Association of lysogenic bacteriophage MAV1 with virulence of Mycoplasma arthritidis</title><title>Infection and Immunity</title><addtitle>Infect Immun</addtitle><description>Mycoplasma arthritidis causes a severe polyarthritis under natural conditions in rats and under experimental conditions in both rats and mice. Although the disease itself has been extensively studied, M. arthritidis virulence factors remain uncharacterized. Comparison of relative arthritogenicity of 20 strains of M. arthritidis revealed that the strains tended to fall into two groups, a highly arthritogenic group, inducing maximum arthritis scores of greater than or equal to 11 in rats, and a low-virulence group, inducing maximum scores of 6. Chromosomal DNA from the more highly arthritogenic strains possessed sequences that hybridized by Southern analysis with a probe prepared from lysogenic M. arthritidis bacteriophage MAV1, while DNA from low-virulence strains did not. One of the low-virulence strains, 158, was experimentally lysogenized with MAV1. Lysogenized 158 showed a significant increase in arthritogenicity over nonlysogenized 158. These data suggest that MAV1 carries a factor that is important in pathogenesis of M. arthritidis-induced arthritis of rats</description><subject>Animals</subject><subject>Arthritis, Infectious - etiology</subject><subject>BACTERIOFAGOS</subject><subject>Bacteriology</subject><subject>BACTERIOPHAGE</subject><subject>Bacteriophages - genetics</subject><subject>Bacteriophages - pathogenicity</subject><subject>Biological and medical sciences</subject><subject>CHROMOSOME</subject><subject>CROMOSOMAS</subject><subject>DIFERENCIAS BIOLOGICAS</subject><subject>DIFFERENCE BIOLOGIQUE</subject><subject>DNA, Viral - analysis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIBRIDACION DE ADN</subject><subject>HYBRIDATION D'ADN</subject><subject>Lysogeny</subject><subject>Male</subject><subject>Microbiology</subject><subject>MYCOPLASMA</subject><subject>Mycoplasma - pathogenicity</subject><subject>Mycoplasma - virology</subject><subject>Mycoplasma arthritidis</subject><subject>Nucleic Acid Hybridization</subject><subject>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</subject><subject>PATOGENICIDAD</subject><subject>POUVOIR PATHOGENE</subject><subject>RAT</subject><subject>RATA</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>SECUENCIA NUCLEOTIDICA</subject><subject>SEQUENCE NUCLEOTIDIQUE</subject><subject>Virulence</subject><issn>0019-9567</issn><issn>1098-5522</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNp9kUtvEzEUhS0EKqHwB5CQRqhiN8EevxcsoopHpFYsaNlaNx57xmgyDvakVf49HhJFwIKVdXS_cx8-CFUELwlp1Pv1ar0UdFkkw0TUDDdFaM2foAXBWtWcN81TtMCY6FpzIZ-jFzn_KJIxpi7QheRcUUIX6G6Vc7QBphDHKvpqOOTYuTHYagN2cinEXQ-dq25X30n1GKa-eghpP7jRuhm_Pdi4GyBvoYI09SlMoQ35JXrmYcju1em9RPefPt5df6lvvn5eX69uassbPNXQMqpUYyloLjElLQXCudQt8UrzpqWeyQYU3ghNgDGqtdeMO7pRzCvQml6iD8e-u_1m61rrxinBYHYpbCEdTIRg_q6MoTddfDBEUi5Y8b87-VP8uXd5MtuQrRsGGF3cZyMlL9_7e9D_QSI0V0SQAqojaFPMOTl_XoZgMydnQllK0FnOyZk5OTMnV6xv_jzmbDxFVepXpzpkC4NPMNqQzxgVQlE6t3l7xPrQ9Y8hOVPS-WdqgV4fIQ_RQJdKn_tvWmJBOKW_AJTXtfM</recordid><startdate>19951001</startdate><enddate>19951001</enddate><creator>Voelker, L.L. (University of Alabama, Birmingham, Birmingham, AL.)</creator><creator>Weaver, K.E</creator><creator>Ehle, L.J</creator><creator>Washburn, L.R</creator><general>American Society for Microbiology</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19951001</creationdate><title>Association of lysogenic bacteriophage MAV1 with virulence of Mycoplasma arthritidis</title><author>Voelker, L.L. (University of Alabama, Birmingham, Birmingham, AL.) ; Weaver, K.E ; Ehle, L.J ; Washburn, L.R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-ad43882c3a957031d3a15579d1f8952d3f472a80b691a44399f945e3b84f8a993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Arthritis, Infectious - etiology</topic><topic>BACTERIOFAGOS</topic><topic>Bacteriology</topic><topic>BACTERIOPHAGE</topic><topic>Bacteriophages - genetics</topic><topic>Bacteriophages - pathogenicity</topic><topic>Biological and medical sciences</topic><topic>CHROMOSOME</topic><topic>CROMOSOMAS</topic><topic>DIFERENCIAS BIOLOGICAS</topic><topic>DIFFERENCE BIOLOGIQUE</topic><topic>DNA, Viral - analysis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HIBRIDACION DE ADN</topic><topic>HYBRIDATION D'ADN</topic><topic>Lysogeny</topic><topic>Male</topic><topic>Microbiology</topic><topic>MYCOPLASMA</topic><topic>Mycoplasma - pathogenicity</topic><topic>Mycoplasma - virology</topic><topic>Mycoplasma arthritidis</topic><topic>Nucleic Acid Hybridization</topic><topic>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</topic><topic>PATOGENICIDAD</topic><topic>POUVOIR PATHOGENE</topic><topic>RAT</topic><topic>RATA</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>SECUENCIA NUCLEOTIDICA</topic><topic>SEQUENCE NUCLEOTIDIQUE</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Voelker, L.L. (University of Alabama, Birmingham, Birmingham, AL.)</creatorcontrib><creatorcontrib>Weaver, K.E</creatorcontrib><creatorcontrib>Ehle, L.J</creatorcontrib><creatorcontrib>Washburn, L.R</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Infection and Immunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Voelker, L.L. (University of Alabama, Birmingham, Birmingham, AL.)</au><au>Weaver, K.E</au><au>Ehle, L.J</au><au>Washburn, L.R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of lysogenic bacteriophage MAV1 with virulence of Mycoplasma arthritidis</atitle><jtitle>Infection and Immunity</jtitle><addtitle>Infect Immun</addtitle><date>1995-10-01</date><risdate>1995</risdate><volume>63</volume><issue>10</issue><spage>4016</spage><epage>4023</epage><pages>4016-4023</pages><issn>0019-9567</issn><eissn>1098-5522</eissn><coden>INFIBR</coden><abstract>Mycoplasma arthritidis causes a severe polyarthritis under natural conditions in rats and under experimental conditions in both rats and mice. Although the disease itself has been extensively studied, M. arthritidis virulence factors remain uncharacterized. Comparison of relative arthritogenicity of 20 strains of M. arthritidis revealed that the strains tended to fall into two groups, a highly arthritogenic group, inducing maximum arthritis scores of greater than or equal to 11 in rats, and a low-virulence group, inducing maximum scores of 6. Chromosomal DNA from the more highly arthritogenic strains possessed sequences that hybridized by Southern analysis with a probe prepared from lysogenic M. arthritidis bacteriophage MAV1, while DNA from low-virulence strains did not. One of the low-virulence strains, 158, was experimentally lysogenized with MAV1. Lysogenized 158 showed a significant increase in arthritogenicity over nonlysogenized 158. 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| identifier | ISSN: 0019-9567 |
| ispartof | Infection and Immunity, 1995-10, Vol.63 (10), p.4016-4023 |
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| language | eng |
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| source | American Society for Microbiology (ASM) Journals; PubMed Central |
| subjects | Animals Arthritis, Infectious - etiology BACTERIOFAGOS Bacteriology BACTERIOPHAGE Bacteriophages - genetics Bacteriophages - pathogenicity Biological and medical sciences CHROMOSOME CROMOSOMAS DIFERENCIAS BIOLOGICAS DIFFERENCE BIOLOGIQUE DNA, Viral - analysis Fundamental and applied biological sciences. Psychology HIBRIDACION DE ADN HYBRIDATION D'ADN Lysogeny Male Microbiology MYCOPLASMA Mycoplasma - pathogenicity Mycoplasma - virology Mycoplasma arthritidis Nucleic Acid Hybridization Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains PATOGENICIDAD POUVOIR PATHOGENE RAT RATA Rats Rats, Inbred Lew SECUENCIA NUCLEOTIDICA SEQUENCE NUCLEOTIDIQUE Virulence |
| title | Association of lysogenic bacteriophage MAV1 with virulence of Mycoplasma arthritidis |
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