Serum antibody responses of cattle following experimental infection with Escherichia coli O157:H7

Oral inoculation of calves and steers with 10(10) CFU of Escherichia coli O157:H7 induced prompt and sustained increases in serum antibodies to O157 lipopolysaccharide. Neutralizing antibodies to verotoxin 1 also increased rapidly in most steers but more gradually in calves. None of the animals deve...

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Bibliographic Details
Published in:Infection and Immunity 1996-05, Vol.64 (5), p.1879-1883
Main Authors: Johnson, R.P. (Agriculture and Agri-Food Canada, Guelph, Ontario, Canada.), Cray, W.C. Jr, Johnson, S.T
Format: Article
Language:English
Subjects:
Animals
Antibodies, Bacterial - blood
ANTICORPS
ANTICUERPOS
Bacterial diseases
Bacterial Toxins - immunology
Biological and medical sciences
Brucella abortus - immunology
Cattle
Cross Reactions
Disease Models, Animal
ESCHERICHIA COLI
Escherichia coli - immunology
Escherichia coli Infections - immunology
Escherichia coli Infections - prevention & control
Experimental bacterial diseases and models
Infectious diseases
Lipopolysaccharides - immunology
Male
Medical sciences
Neutralization Tests
Shiga Toxin 1
Shiga Toxin 2
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Summary:Oral inoculation of calves and steers with 10(10) CFU of Escherichia coli O157:H7 induced prompt and sustained increases in serum antibodies to O157 lipopolysaccharide. Neutralizing antibodies to verotoxin 1 also increased rapidly in most steers but more gradually in calves. None of the animals developed neutralizing antibodies to verotoxin 2. These serological responses were not correlated with elimination of infection in calves or steers or protection of calves against reinfection with the same strain
ISSN:0019-9567
1098-5522
DOI:10.1128/iai.64.5.1879-1883.1996