A meta-analysis of Italian and Estonian individuals shows an effect of common variants in

The aim of the study was to explore the effects of variants at on a range of cardio-metabolic phenotypes. We analyzed the range of variants within Genetics in Brisighella Health Study and genes using an additive genetic model on 18 cardiometabolic phenotypes in a sample of 1645 individuals from the...

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Published in:Biomarkers in medicine 2018-09, Vol.13 (11), p.931-940
Main Authors: Rosticci, Martina, Pervjakova, Natalia, Kaakinen, Marika, Cicero, Arrigo F, Feufer, Arne P, Marullo, Letizia, Mägi, Reedik, Fischer, Krista, Jiang, Longda, D'Addato, Sergio, Rizzoli, Elisabetta, Massimo, Gianmichele, Giovannini, Marina, Angelini, Sabrina, Hrelia, Patrizia, Scapoli, Chiara, Borghi, Claudio, Prokopenko, Inga
Format: Article
Language:English
Subjects:
ApoB
blood lipids
cardiovascular disease
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Summary:The aim of the study was to explore the effects of variants at on a range of cardio-metabolic phenotypes. We analyzed the range of variants within Genetics in Brisighella Health Study and genes using an additive genetic model on 18 cardiometabolic phenotypes in a sample of 1645 individuals from the Genetics in Brisighella Health Study and replicated in 10,662 individuals from the Estonian Genome Center University of Tartu. We defined directly the effects of rs3846662:C>A at on apoB levels. The analysis also confirmed effects of on low-density lipoprotein-cholesterol and total cholesterol levels. Variants in gene did not reveal any associations with cardiometabolic phenotypes. This study highlights effect of locus on assay-determined apoB levels, an infrequent measure of blood lipids in large studies.
ISSN:1752-0363
1752-0371
DOI:10.2217/bmm-2017-0431