Loss of the tRNA

To investigate the presence/absence of the gene as a marker for genetic predisposition to Type 2 diabetes mellitus (T2DM). We enrolled 122 patients diagnosed with T2DM and 77 non-diabetic individuals. We evaluated clinical and biochemical parameters (body mass index, hypertension, cholesterol levels...

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Bibliographic Details
Published in:Biomarkers in medicine 2019-03, Vol.13 (4), p.259-266
Main Authors: Yang, Pablo, Beltramo, Dante Miguel, de Pouplana, Lluís Ribas, Soria, Néstor Walter, Torres, Adrian Gabriel
Format: Article
Language:English
Subjects:
biomarker
gene translation
genotypic profiling
insulin
PCR
T2DM
tRNA
tRNA gene
tRNA-Lys-CUU
Type 2 diabetes mellitus
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Summary:To investigate the presence/absence of the gene as a marker for genetic predisposition to Type 2 diabetes mellitus (T2DM). We enrolled 122 patients diagnosed with T2DM and 77 non-diabetic individuals. We evaluated clinical and biochemical parameters (body mass index, hypertension, cholesterol levels, glycosylated hemoglobin, triglycerides, etc.), and performed a genotypic profiling of by polymerase chain reaction analyses. Approximately one third of the population lacked . We did not observe a statistically significant association between the presence/absence of and T2DM. The genotypic distribution of in our population was consistent to that reported by others. This gene failed as a marker for T2DM predisposition.
ISSN:1752-0363
1752-0371
DOI:10.2217/bmm-2018-0322