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Loss of the tRNA
To investigate the presence/absence of the gene as a marker for genetic predisposition to Type 2 diabetes mellitus (T2DM). We enrolled 122 patients diagnosed with T2DM and 77 non-diabetic individuals. We evaluated clinical and biochemical parameters (body mass index, hypertension, cholesterol levels...
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| Published in: | Biomarkers in medicine 2019-03, Vol.13 (4), p.259-266 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 266 |
| container_issue | 4 |
| container_start_page | 259 |
| container_title | Biomarkers in medicine |
| container_volume | 13 |
| creator | Yang, Pablo Beltramo, Dante Miguel de Pouplana, Lluís Ribas Soria, Néstor Walter Torres, Adrian Gabriel |
| description | To investigate the presence/absence of the
gene as a marker for genetic predisposition to Type 2 diabetes mellitus (T2DM).
We enrolled 122 patients diagnosed with T2DM and 77 non-diabetic individuals. We evaluated clinical and biochemical parameters (body mass index, hypertension, cholesterol levels, glycosylated hemoglobin, triglycerides, etc.), and performed a genotypic profiling of
by polymerase chain reaction analyses.
Approximately one third of the population lacked
. We did not observe a statistically significant association between the presence/absence of
and T2DM.
The genotypic distribution of
in our population was consistent to that reported by others. This gene failed as a marker for T2DM predisposition. |
| doi_str_mv | 10.2217/bmm-2018-0322 |
| format | article |
| fullrecord | <record><control><sourceid>futurescience</sourceid><recordid>TN_cdi_futurescience_futuremedicine_10_2217_bmm_2018_0322</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_2217_bmm_2018_0322</sourcerecordid><originalsourceid>FETCH-futurescience_futuremedicine_10_2217_bmm_2018_03223</originalsourceid><addsrcrecordid>eNpjYBA1NNAzMjI010_KzdU1MjC00DUwNjJiYuA0NDc1ArLNDVngbDNjDgau4uIsAwNTc3MzI04GAZ_84mKF_DSFkoxUhZIgP0ceBta0xJziVF4ozc1g6eYa4uyhm1ZaUlqUWpycmZqXnBoP4eWmpmQmZ-alxhsaxIOcEA90QjzICfEgJxhTohcAwbc8HA</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Loss of the tRNA</title><source>Open Access: PubMed Central</source><creator>Yang, Pablo ; Beltramo, Dante Miguel ; de Pouplana, Lluís Ribas ; Soria, Néstor Walter ; Torres, Adrian Gabriel</creator><creatorcontrib>Yang, Pablo ; Beltramo, Dante Miguel ; de Pouplana, Lluís Ribas ; Soria, Néstor Walter ; Torres, Adrian Gabriel</creatorcontrib><description>To investigate the presence/absence of the
gene as a marker for genetic predisposition to Type 2 diabetes mellitus (T2DM).
We enrolled 122 patients diagnosed with T2DM and 77 non-diabetic individuals. We evaluated clinical and biochemical parameters (body mass index, hypertension, cholesterol levels, glycosylated hemoglobin, triglycerides, etc.), and performed a genotypic profiling of
by polymerase chain reaction analyses.
Approximately one third of the population lacked
. We did not observe a statistically significant association between the presence/absence of
and T2DM.
The genotypic distribution of
in our population was consistent to that reported by others. This gene failed as a marker for T2DM predisposition.</description><identifier>ISSN: 1752-0363</identifier><identifier>EISSN: 1752-0371</identifier><identifier>DOI: 10.2217/bmm-2018-0322</identifier><language>eng</language><publisher>Future Medicine Ltd</publisher><subject>biomarker ; gene translation ; genotypic profiling ; insulin ; PCR ; T2DM ; tRNA ; tRNA gene ; tRNA-Lys-CUU ; Type 2 diabetes mellitus</subject><ispartof>Biomarkers in medicine, 2019-03, Vol.13 (4), p.259-266</ispartof><rights>2019 Future Medicine Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids></links><search><creatorcontrib>Yang, Pablo</creatorcontrib><creatorcontrib>Beltramo, Dante Miguel</creatorcontrib><creatorcontrib>de Pouplana, Lluís Ribas</creatorcontrib><creatorcontrib>Soria, Néstor Walter</creatorcontrib><creatorcontrib>Torres, Adrian Gabriel</creatorcontrib><title>Loss of the tRNA</title><title>Biomarkers in medicine</title><description>To investigate the presence/absence of the
gene as a marker for genetic predisposition to Type 2 diabetes mellitus (T2DM).
We enrolled 122 patients diagnosed with T2DM and 77 non-diabetic individuals. We evaluated clinical and biochemical parameters (body mass index, hypertension, cholesterol levels, glycosylated hemoglobin, triglycerides, etc.), and performed a genotypic profiling of
by polymerase chain reaction analyses.
Approximately one third of the population lacked
. We did not observe a statistically significant association between the presence/absence of
and T2DM.
The genotypic distribution of
in our population was consistent to that reported by others. This gene failed as a marker for T2DM predisposition.</description><subject>biomarker</subject><subject>gene translation</subject><subject>genotypic profiling</subject><subject>insulin</subject><subject>PCR</subject><subject>T2DM</subject><subject>tRNA</subject><subject>tRNA gene</subject><subject>tRNA-Lys-CUU</subject><subject>Type 2 diabetes mellitus</subject><issn>1752-0363</issn><issn>1752-0371</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNpjYBA1NNAzMjI010_KzdU1MjC00DUwNjJiYuA0NDc1ArLNDVngbDNjDgau4uIsAwNTc3MzI04GAZ_84mKF_DSFkoxUhZIgP0ceBta0xJziVF4ozc1g6eYa4uyhm1ZaUlqUWpycmZqXnBoP4eWmpmQmZ-alxhsaxIOcEA90QjzICfEgJxhTohcAwbc8HA</recordid><startdate>20190301</startdate><startdate>20190301</startdate><enddate>20190301</enddate><enddate>20190301</enddate><creator>Yang, Pablo</creator><creator>Beltramo, Dante Miguel</creator><creator>de Pouplana, Lluís Ribas</creator><creator>Soria, Néstor Walter</creator><creator>Torres, Adrian Gabriel</creator><general>Future Medicine Ltd</general><scope/></search><sort><creationdate>20190301</creationdate><title>Loss of the tRNA</title><author>Yang, Pablo ; Beltramo, Dante Miguel ; de Pouplana, Lluís Ribas ; Soria, Néstor Walter ; Torres, Adrian Gabriel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-futurescience_futuremedicine_10_2217_bmm_2018_03223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>biomarker</topic><topic>gene translation</topic><topic>genotypic profiling</topic><topic>insulin</topic><topic>PCR</topic><topic>T2DM</topic><topic>tRNA</topic><topic>tRNA gene</topic><topic>tRNA-Lys-CUU</topic><topic>Type 2 diabetes mellitus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Pablo</creatorcontrib><creatorcontrib>Beltramo, Dante Miguel</creatorcontrib><creatorcontrib>de Pouplana, Lluís Ribas</creatorcontrib><creatorcontrib>Soria, Néstor Walter</creatorcontrib><creatorcontrib>Torres, Adrian Gabriel</creatorcontrib><jtitle>Biomarkers in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Pablo</au><au>Beltramo, Dante Miguel</au><au>de Pouplana, Lluís Ribas</au><au>Soria, Néstor Walter</au><au>Torres, Adrian Gabriel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Loss of the tRNA</atitle><jtitle>Biomarkers in medicine</jtitle><date>2019-03-01</date><date>2019-03-01</date><risdate>2019</risdate><risdate>2019</risdate><volume>13</volume><issue>4</issue><spage>259</spage><epage>266</epage><pages>259-266</pages><issn>1752-0363</issn><eissn>1752-0371</eissn><abstract>To investigate the presence/absence of the
gene as a marker for genetic predisposition to Type 2 diabetes mellitus (T2DM).
We enrolled 122 patients diagnosed with T2DM and 77 non-diabetic individuals. We evaluated clinical and biochemical parameters (body mass index, hypertension, cholesterol levels, glycosylated hemoglobin, triglycerides, etc.), and performed a genotypic profiling of
by polymerase chain reaction analyses.
Approximately one third of the population lacked
. We did not observe a statistically significant association between the presence/absence of
and T2DM.
The genotypic distribution of
in our population was consistent to that reported by others. This gene failed as a marker for T2DM predisposition.</abstract><pub>Future Medicine Ltd</pub><doi>10.2217/bmm-2018-0322</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1752-0363 |
| ispartof | Biomarkers in medicine, 2019-03, Vol.13 (4), p.259-266 |
| issn | 1752-0363 1752-0371 |
| language | eng |
| recordid | cdi_futurescience_futuremedicine_10_2217_bmm_2018_0322 |
| source | Open Access: PubMed Central |
| subjects | biomarker gene translation genotypic profiling insulin PCR T2DM tRNA tRNA gene tRNA-Lys-CUU Type 2 diabetes mellitus |
| title | Loss of the tRNA |
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