The putative

To investigate the regulatory potential of the second intron within the micro-imprinted domain. Mice with deletion of second intron at the endogenous micro-imprinted domain were used to examine the effect of second intron on the transcriptional regulation of the and genes. Deletion of second intron...

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Bibliographic Details
Published in:Epigenomics 2019-02, Vol.11 (3), p.251-266
Main Authors: Thamban, Thushara, Sowpati, Divya Tej, Pai, Vaishnavo, Nithianandam, Vanitha, Abe, Takaya, Shioi, Go, Mishra, Rakesh K, Khosla, Sanjeev
Format: Article
Language:English
Subjects:
DNA methylation
genomic imprinting
histone modifications
Online Access:Get full text
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Summary:To investigate the regulatory potential of the second intron within the micro-imprinted domain. Mice with deletion of second intron at the endogenous micro-imprinted domain were used to examine the effect of second intron on the transcriptional regulation of the and genes. Deletion of second intron affected expression in leading to the loss of expression from the active paternal allele. second intron was found to have the characteristics of an imprint control region including allele-specific DNA methylation and histone modifications and it also regulated the epigenetic profile of promoter by acting as an enhancer. second intron was also found to be regulating the expression of the transcripts.
ISSN:1750-1911
1750-192X
DOI:10.2217/epi-2018-0060