A review of telavancin activity in

Tissue- and device-associated biofilm infections are important medical problems. These infections are difficult to treat due to a high-level of tolerance to antibiotics. Telavancin has been studied in several biofilm models and has demonstrated efficacy against staphylococcal and enterococcal-associ...

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Bibliographic Details
Published in:Future microbiology 2015-08, Vol.10 (8), p.1325-1338
Main Authors: Chan, Cynthia, Hardin, Thomas C, Smart, Jennifer I
Format: Article
Language:English
Subjects:
biofilm
device-associated infections
endocarditis
osteomyelitis
telavancin
Online Access:Get full text
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Summary:Tissue- and device-associated biofilm infections are important medical problems. These infections are difficult to treat due to a high-level of tolerance to antibiotics. Telavancin has been studied in several biofilm models and has demonstrated efficacy against staphylococcal and enterococcal-associated biofilm infections, including those formed by methicillin-resistant . Telavancin was effective against the difficult-to-treat vancomycin- and glycopeptide-intermediate strains of in these models. Furthermore, the efficacy of telavancin has been evaluated in several biofilm-related models, including osteomyelitis, endocarditis and device-associated infections in rabbits. Overall, telavancin exhibited similar or greater efficacy than vancomycin and other comparators in these animal models and maintained activity against vancomycin-intermediate and daptomycin nonsusceptible strains of .
ISSN:1746-0913
1746-0921
DOI:10.2217/fmb.15.53