Novel nano-sized chitosan amphotericin B formulation with considerable improvement against

Improvement in the treatment of 's pathological effects through increasing the dose of amphotericin B loaded into nanochitosan. The phase separation method was used for nanochitosan synthesis and amphotericin loading. Also a novel solvent was designed and the nanodrug efficacy was evaluated and...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2018-12, Vol.13 (24), p.3129-3147
Main Authors: Mehrizi, Tahereh Zadeh, Ardestani, Mehdi Shafiee, Molla Hoseini, Mostafa Haji, Khamesipour, Ali, Mosaffa, Nariman, Ramezani, Amitis
Format: Article
Language:English
Subjects:
increasing effective therapeutic dose
nanochitosan
phase separation
toxicity reduction
Online Access:Get full text
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Summary:Improvement in the treatment of 's pathological effects through increasing the dose of amphotericin B loaded into nanochitosan. The phase separation method was used for nanochitosan synthesis and amphotericin loading. Also a novel solvent was designed and the nanodrug efficacy was evaluated and (pathology) environments. The drug loading efficiency of 90%, along with slow drug-release with cellular uptake of 98.6% was achieved. The novel solvent was composed of 10% acetic acid, and it was succeeded to dissolve AK10 mg/kg. Also, AK10 mg/kg had no side effects in and environments. In addition, the complete wound healing and parasite inhibition were achieved by using AK10 mg/kg in terms of improvement the treatment indicators. Increasing the therapeutic dose of AK to 10 mg/kg caused the successful treatment of 's pathological effects in and environments.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2018-0063