Comparison of a multiple daily insulin injection regimen

Aims. To examine the potential differences between multiple daily injection (MDI) regimens based on new long-acting insulin analogues (glargine or detemir) plus prandial insulin aspart and continuous subcutaneous insulin aspart infusion (CSII) in patients with poorly controlled type 2 diabetes. Meth...

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Bibliographic Details
Published in:International journal of endocrinology 2013-01
Main Authors: Gao, Yan-yan, Xian, Yu- xin, Wen, Jun-ping, Li, Li, Cao, Cai-xia, Pan, Rong-fang, Sun, Rui-xia, Wang, Jing, Lv, Wen-shan
Format: Article
Language:English
Subjects:
Body weight
Care and treatment
Glucose metabolism
Health aspects
Risk factors
Type 2 diabetes
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Summary:Aims. To examine the potential differences between multiple daily injection (MDI) regimens based on new long-acting insulin analogues (glargine or detemir) plus prandial insulin aspart and continuous subcutaneous insulin aspart infusion (CSII) in patients with poorly controlled type 2 diabetes. Methods. Patients (n = 119) with poorly controlled type 2 diabetes of a duration exceeding five years were randomly assigned into three groups: Group A treated with CSII using insulin aspart; Group B treated with glarginebased MDI and Group C treated with detemir-based MDI. Results. Good glycemic control was achieved by patients in Group A in a significantly shorter duration than patients in Groups B and C. Total daily insulin, basal insulin dose and dose per kg body weight in Group A were significantly less than those in Groups B and C. Daily blood glucose fluctuation in Group A was significantly less than that in Groups B and C. There were no differences between Groups B and C. Conclusions. Aspart-based CSII may achieve good blood glucose control with less insulin doses over a shorter period compared with glargine or detemir-based MDI. No differences between glargine- and detemir-based MDI were detected in poorly controlled subjects with type 2 diabetes.
ISSN:1687-8337